RGD-based PET tracers for imaging receptor integrin αvβ3 expression

被引：67
作者：
Cai, Hancheng [1 ,2 ]
Conti, Peter S. [3 ]
机构：
[1] Childrens Hosp Michigan, Detroit Med Ctr, PET Ctr, Detroit, MI 48201 USA
[2] Wayne State Univ, Sch Med, Detroit, MI 48201 USA
[3] Univ So Calif, Keck Sch Med, Dept Radiol, Mol Imaging Ctr, Los Angeles, CA 90033 USA
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2013年 / 56卷 / 05期
关键词：
PET imaging; radiochemistry; integrin; RGD; POSITRON-EMISSION-TOMOGRAPHY; GLY-ASP PEPTIDE; CLICK CHEMISTRY; BREAST-CANCER; COPPER-64; RADIOPHARMACEUTICALS; ALPHA-V-BETA-3; INTEGRIN; BIFUNCTIONAL CHELATOR; BIOLOGICAL EVALUATION; RADIATION-DOSIMETRY; TARGETED DELIVERY;
D O I：
10.1002/jlcr.2999
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Positron emission tomography (PET) imaging of receptor integrin alpha(v)beta(3) expression may play a key role in the early detection of cancer and cardiovascular diseases, monitoring disease progression, evaluating therapeutic response, and aiding anti-angiogenic drugs discovery and development. The last decade has seen the development of new PET tracers for in vivo imaging of integrin alpha(v)beta(3) expression along with advances in PET chemistry. In this review, we will focus on the radiochemistry development of PET tracers based on arginineglycineaspartic acid (RGD) peptide, present an overview of general strategies for preparing RGD-based PET tracers, and review the recent advances in preparations of F-18-labeled, Cu-64-labeled, and Ga-68-labeled RGD tracers, RGD-based PET multivalent probes, and RGD-based PET multimodality probes for imaging receptor integrin alpha(v)beta(3) expression.
引用
收藏
页码：264 / 279
页数：16
相关论文
共 141 条
[1]   Copper-64 Radiopharmaceuticals for PET Imaging of Cancer: Advances in Preclinical and Clinical Research [J].
Anderson, Carolyn J. ;
Ferdani, Riccardo .
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2009, 24 (04) :379-393
[2]   Monitoring Tumor Response to Antiangiogenic Sunitinib Therapy with 18F-Fluciclatide, an 18F-Labeled αvβ3-Integrin and αvβ5-Integrin Imaging Agent [J].
Battle, Mark R. ;
Goggi, Julian L. ;
Allen, Lucy ;
Barnett, Jon ;
Morrison, Matthew S. .
JOURNAL OF NUCLEAR MEDICINE, 2011, 52 (03) :424-430
[3]   Direct One-Step18F-Labeling of Peptides via Nucleophilic Aromatic Substitution [J].
Becaud, Jessica ;
Mu, Linjing ;
Karramkam, Mylene ;
Schubiger, Pius A. ;
Ametamey, Simon M. ;
Graham, Keith ;
Stellfeld, Timo ;
Lehmann, Lutz ;
Borkowski, Sandra ;
Berndorff, Dietmar ;
Dinkelborg, Ludger ;
Srinivasan, Ananth ;
Smits, Rene ;
Koksch, Beate .
BIOCONJUGATE CHEMISTRY, 2009, 20 (12) :2254-2261
[4]  
Beer AJ, 2006, J NUCL MED, V47, P763
[5]  
Beer AJ, 2005, J NUCL MED, V46, P1333
[6]   Patterns of αvβ3 expression in primary and metastatic human breast cancer as shown by 18F-galacto-RGD PET [J].
Beer, Ambros J. ;
Niemeyer, Markus ;
Carlsen, Janette ;
Sarbia, Mario ;
Naehrig, Joerg ;
Watzlowik, Petra ;
Wester, Hans-Juergen ;
Harbeck, Nadia ;
Schwaiger, Markus .
JOURNAL OF NUCLEAR MEDICINE, 2008, 49 (02) :255-259
[7]   Comparison of integrin αvβ3 expression and glucose metabolism in primary and metastatic lesions in cancer patients:: A PET study using 18F-galacto-RGD and 18F-FDG [J].
Beer, Ambros J. ;
Lorenzen, Sylvie ;
Metz, Stephan ;
Herrmann, Ken ;
Watzlowikl, Petra ;
Wester, Hans-Juergen ;
Pesche, Christian ;
Lordick, Florian ;
Schwaiger, Markus .
JOURNAL OF NUCLEAR MEDICINE, 2008, 49 (01) :22-29
[8]   [18F]Galacto-RGD positron emission tomography for imaging of αvβ3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck [J].
Beer, Ambros J. ;
Grosu, Anca-Ligia ;
Carlsen, Janette ;
Kolk, Andreas ;
Sarbia, Mario ;
Stangier, Isabelle ;
Watzlowik, Petra ;
Wester, Hans-Juergen ;
Haubner, Roland ;
Schwaiger, Markus .
CLINICAL CANCER RESEARCH, 2007, 13 (22) :6610-6616
[9]   Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin αvβ3 expression in man [J].
Beer, Ambros J. ;
Haubner, Roland ;
Sarbia, Mario ;
Goebel, Michael ;
Luderschmidt, Stephan ;
Grosu, Anca Ligia ;
Schnell, Oliver ;
Niemeyer, Markus ;
Kessler, Horst ;
Wester, Hans-Juergen ;
Weber, Wolfgang A. ;
Schwaiger, Markus .
CLINICAL CANCER RESEARCH, 2006, 12 (13) :3942-3949
[10]   PET Imaging of Integrin αVβ3 Expression [J].
Beer, Ambros J. ;
Kessler, Horst ;
Wester, Hans-Juergen ;
Schwaiger, Markus .
THERANOSTICS, 2011, 1 :48-57
12345678910