Anti-tumor and anti-viral activities of Galanthus nivalis agglutinin (GNA)-related lectins

被引：33
作者：
Wu, Lei [1 ,2 ]
Bao, Jin-ku [1 ,2 ]
机构：
[1] Sichuan Univ, Sch Life Sci, Minist Educ, Chengdu 610064, Peoples R China
[2] Sichuan Univ, Key Lab Bioresources & Ecoenvironm, Minist Educ, Chengdu 610064, Peoples R China
来源：
GLYCOCONJUGATE JOURNAL | 2013年 / 30卷 / 03期
基金：
中国国家自然科学基金;
关键词：
GNA-related lectins; Anti-tumor; Anti-viral; Drugs; HUMAN-IMMUNODEFICIENCY-VIRUS; POLYGONATUM-CYRTONEMA LECTIN; MANNOSE-BINDING LECTIN; PROTEIN-KINASE PATHWAY; PROGRAMMED CELL-DEATH; PLANT-LECTINS; MOLECULAR-CLONING; DC-SIGN; CARBOHYDRATE INTERACTIONS; OSCILLATORIA-AGARDHII;
D O I：
10.1007/s10719-012-9440-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Galanthus nivalis agglutinin (GNA)-related lectin family, a superfamily of strictly mannose-binding specific lectins widespread among monocotyledonous plants, is well-known to possess a broad range of biological functions such as anti-tumor, anti-viral and anti-fungal activities. Herein, we mainly focused on exploring the precise molecular mechanisms by which GNA-related lectins induce cancer cell apoptotic and autophagic death targeting mitochondria-mediated ROS-p38-p53 apoptotic or autophagic pathway, Ras-Raf and PI3K-Akt anti-apoptotic or anti-autophagic pathways. In addition, we further discussed the molecular mechanisms of GNA-related lectins exerting anti-viral activities by blocking the entry of the virus into its target cells, preventing transmission of the virus as well as forcing virus to delete glycan in its envelope protein and triggering neutralizing antibody. In conclusion, these findings may provide a new perspective of GNA-related lectins as potential drugs for cancer and virus therapeutics in the future.
引用
收藏
页码：269 / 279
页数：11
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