Advances with RNA interference in Alzheimer's disease research

被引：34
作者：
Chen, Shun [1 ,2 ]
Ge, Xuemei [2 ]
Chen, Yinghui [3 ]
Lv, Nan [2 ]
Liu, Zhenguo [1 ]
Yuan, Weien [2 ]
机构：
[1] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Neurol, Shanghai 200092, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200092, Peoples R China
[3] Fudan Univ, Jinshan Hosp, Dept Neurol, Shanghai 200433, Peoples R China
来源：
DRUG DESIGN DEVELOPMENT AND THERAPY | 2013年 / 7卷
基金：
美国国家科学基金会;
关键词：
RNAi; beta-amyloid; tau; amyloid precursor protein; AMYLOID PRECURSOR PROTEIN; BETA-SECRETASE CLEAVAGE; NEUROFIBRILLARY TANGLES; CURRENT PROGRESS; ALPHA-SECRETASE; TAU; PEPTIDE; LOCALIZATION; THERAPEUTICS; SIRNA;
D O I：
10.2147/DDDT.S40229
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized clinically by memory and cognitive dysfunction. Unfortunately, there is no effective therapeutic method for AD treatment or ways to halt disease progression. Many mechanisms are involved in the disease, including genes mutation and protein dysfunction. RNA interference (RNAi) technology may potentially be able to control AD. It can inhibit the protein expression of specific genes by activating a sequence-specific RNA degradation process. This is a powerful tool with which to study gene function, investigate the mechanism of the disease, and validate drug targets. In this review, we highlight the advances in RNAi technology in the investigation and treatment of AD.
引用
收藏
页码：117 / 125
页数：9
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