Clinical trials of dual-target CAR T cells, donor-derived CAR T cells, and universal CAR T cells for acute lymphoid leukemia

被引：84
作者：
Zhao, Juanjuan [1 ,2 ]
Song, Yongping [1 ,2 ]
Liu, Delong [1 ,2 ]
机构：
[1] Zhengzhou Univ, Affiliated Canc Hosp, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China
[2] Henan Canc Hosp, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China
来源：
JOURNAL OF HEMATOLOGY & ONCOLOGY | 2019年 / 12卷 / 1期
基金：
中国国家自然科学基金;
关键词：
ACUTE LYMPHOBLASTIC-LEUKEMIA; MINI-HYPER-CVD; TERM-FOLLOW-UP; ACUTE LYMPHOCYTIC-LEUKEMIA; LOW-INTENSITY CHEMOTHERAPY; ANTIGEN RECEPTOR THERAPY; B-CELL; INOTUZUMAB OZOGAMICIN; SEQUENTIAL COMBINATION; PEDIATRIC-PATIENTS;
D O I：
10.1186/s13045-019-0705-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The current treatment for pediatric acute lymphoblastic leukemia (ALL) is highly successful with high cure rate. However, the treatment of adult ALL remains a challenge, particularly for refractory and/or relapsed (R/R) ALL. The advent of new targeted agents, blinatumomab, inotuzumab ozogamycin, and chimeric antigen receptor (CAR) T cells, are changing the treatment paradigm for ALL. Tisagenlecleucel (kymriah, Novartis) is an autologous CD19-targeted CAR T cell product approved for treatment of R/R B cell ALL and lymphoma. In an attempt to reduce the relapse rate and treat those relapsed patients with antigen loss, donor-derived CAR T cells and CD19/CD22 dual-target CAR T cells are in clinical trials. Gene-edited "off-the-shelf" universal CAR T cells are also undergoing active clinical development. This review summarized new clinical trials and latest updates at the 2018 ASH Annual Meeting on CAR T therapy for ALL with a focus on dual-target CAR T and universal CAR T cell trials.
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页数：11
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