Cancer Chemoprevention by Polyphenols and Their Potential Application as Nanomedicine

被引：71

作者：

Tabrez, Shams ^{[1
]}

Priyadarshini, Medha ^{[2
]}

Urooj, Maryam ^{[2
]}

Shakil, Shazi ^{[3
]}

Ashraf, Ghulam Md ^{[1
]}

Khan, Mohd Shahnawaz ^{[4
]}

Kamal, Mohammad Amjad ^{[1
]}

Alam, Qamre ^{[1
]}

Jabir, Nasimudeen R. ^{[1
]}

Abuzenadah, Adel Mohammad ^{[1
]}

Chaudhary, Adeel G. A. ^{[1
]}

Damanhouri, Ghazi Abdullah ^{[1
]}

机构：

[1] King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah 21589, Saudi Arabia

[2] AMU, Dept Biochem, Fac Life Sci, Aligarh, Uttar Pradesh, India

[3] Integral Univ, Dept Bioengn, Lucknow, Uttar Pradesh, India

[4] King Saud Univ, Coll Sci, Prot Res Chair, Dept Biochem, Riyadh 11451, Saudi Arabia

来源：

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS | 2013年 / 31卷 / 01期

关键词：

cancer; chemoprevention; chemotherapy; polyphenols; nanotechnology; nanomedicine; GROWTH-FACTOR RECEPTOR; BLACK TEA POLYPHENOLS; CELL-CYCLE ARREST; FACTOR-KAPPA-B; GREEN TEA; EPIGALLOCATECHIN GALLATE; IN-VITRO; ASCORBIC-ACID; DOWN-REGULATION; ELLAGIC ACID;

D O I：

10.1080/10590501.2013.763577

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Today cancer is a leading cause of death among the developed countries. Its highly complex nature makes it difficult to understand as it entails multiple cellular physiological systems such as cell signaling and apoptosis. The biggest challenges faced by cancer chemoprevention/chemotherapy is maintaining drug circulation and avoiding multidrug resistance. Overall there is modest evidence regarding the protective effects of nutrients from supplements against a number of cancers. Numerous scientific literatures available advocate the use of polyphenols for chemoprevention. Some groups have also suggested use of combination of nutrients in cancer prevention. However, we have yet to obtain the desired results in the line of cancer chemotherapy research. Nanotechnology can play a pivotal role in cancer treatment and prevention. Moreover, nanoparticles can be modified in various ways to prolong circulation, enhance drug localization, increase drug efficacy, and potentially decrease the chances of multidrug resistance. In this communication, we will cover the use of various polyphenols and nutrients in cancer chemoprevention. The application of nanotechnology in this regard will also be included. In view of available reports on the potential of nanoparticles, we suggest their usage along with different combination of nutrients as cancer chemotherapeutic agents.

引用

页码：67 / 98

页数：32

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