Synthesis, characterization and in vitro antiprotozoal studies of iron(III) complexes of some antimalarial drugs

被引：17

作者：

Ajibade, Peter A. ^{[1
]}

Kolawole, Gabriel A. ^{[2
]}

机构：

[1] Univ Ft Hare, Dept Chem, ZA-5700 Alice, South Africa

[2] Univ Zululand, Dept Chem, ZA-3886 Kwa Dlangezwa, South Africa

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2008年 / 61卷 / 21期

基金：

新加坡国家研究基金会;

关键词：

Malaria drugs; Iron; Complexes; Parasitic; Drug resistant;

D O I：

10.1080/00958970802072765

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We present the synthesis, characterization and in vitro antiplasmodial and antitrypanosomal studies of iron(III) complexes of amodiaquine, trimethoprim and pyrimethamine. The complexes have been characterized by elemental analyses, electronic and IR spectroscopy and room temperature magnetic susceptibility measurements. The spectra are consistent with octahedral geometry around the metal ions. The complexes were tested for in vitro activity against cultures of Plasmodium falciparum, Tripanosoma brucei rhodosiense, L. donovani and Tripanosoma cruzi. One of the complexes showed enhanced activity of about 8.4 times more than chloroquine against the resistant strain of Plasmodium falciparum.

引用

页码：3367 / 3374

页数：8

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