Cytotoxicity of Meroterpenoids from Sargassum siliquastrum against Human Cancer Cells

被引：0
作者：
Lee, Jung Im [1 ]
Kwak, Myoung K. [2 ]
Park, Hee Y. [1 ]
Seo, Youngwan [2 ]
机构：
[1] Natl Fisheries Res & Dev Inst, Food & Safety Res Ctr, Pusan 619705, South Korea
[2] Korea Maritime Univ, Div Marine Environm & Biosci, Pusan 606791, South Korea
来源：
NATURAL PRODUCT COMMUNICATIONS | 2013年 / 8卷 / 04期
关键词：
Sargassum siliquastrum; Chromanol; Cytotoxicity; Human cancer cells; BROWN-ALGA; NATURAL-PRODUCTS; PREVENTION;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The cytotoxicity of the brown alga Sargassum siliquastrum on human cancer cells (AGS, HT-29, HT-1080, and MCF-7) was investigated. Bioassay-guided fractionation of the crude extracts showed that the 85% aq. methanol (MeOH) fraction was the most toxic. Seven known meroterpenoids (1-7) were isolated from this cytotoxic fraction. Each compound was evaluated for its cytotoxic effect on human cancer cells. Compounds 1, 2, and 4 showed strong cytotoxicity against AGS, HT-29, and HT-1080 cell lines, with IC50 values ranging from 0.5 to 5.7 mu g/mL.
引用
收藏
页码：431 / 432
页数：2
相关论文
共 50 条
  • [21] Cytotoxicity against human cancer cells and lymphocytes based on cerium oxide nanostructures
    Dunna, Manikantha
    Kailasa, Saraswathi
    Saida, Lavudi
    Kumar, P. Jeevan
    Babu, Tumma Gurukiran
    Chepuri, Kalyani
    Rao, K. Venkateswara
    INORGANIC CHEMISTRY COMMUNICATIONS, 2023, 153
  • [22] Cytotoxicity of ZnO Paper against Cancer Cells
    Liao, Su-Yu
    Lin, Jing-Jenn
    Ching, Congo Tak-Shing
    Wu, You-Lin
    SENSORS AND MATERIALS, 2021, 33 (10) : 3389 - 3397
  • [23] Cytotoxicity of n-Butanol Extracts of Streptomyces Against Human Breast Cancer Cells
    Obeidat, Maher
    INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2017, 13 (08) : 969 - 979
  • [24] Preparative isolation of sargachromanol E from Sargassum siliquastrum by centrifugal partition chromatography and its anti-inflammatory activity
    Lee, Ji-Hyeok
    Ko, Ju-Young
    Samarakoon, Kalpa
    Oh, Jae-Young
    Heo, Soo-Jin
    Kim, Chul-Young
    Nah, Jae-Woon
    Jang, Mi-Kyeong
    Lee, Jung-Suck
    Jeon, You-Jin
    FOOD AND CHEMICAL TOXICOLOGY, 2013, 62 : 54 - 60
  • [25] Parasporal Proteins from Bacillus thuringiensis and Their Cytotoxicity on Human Cancer Cells
    WANG Lei
    LV Yuan
    YI Yin-sha
    YI Shang-hui
    LI Lin
    ChineseJournalofBiomedicalEngineering, 2015, 24 (01) : 17 - 27
  • [26] Cytotoxicity and Apoptosis-Induction Potential of Fraction F3 from Fruits of Bersama engleriana (Melanthaceae) against Human Cervical Cancer Cells
    Majoumouo M.S.
    Tincho M.B.
    Morris T.
    Hiss D.C.
    Boyom F.F.
    American Journal of Biochemistry and Biotechnology, 2022, 18 (04) : 428 - 436
  • [27] Cytoprotective effect of fucoxanthin isolated from brown algae Sargassum siliquastrum against H2O2-induced cell damage
    Heo, Soo-Jin
    Ko, Seok-Chun
    Kang, Sung-Myung
    Kang, Hahk-Soo
    Kim, Jong-Pyung
    Kim, Soo-Hyun
    Lee, Ki-Wan
    Cho, Man-Gi
    Jeon, You-Jin
    EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 2008, 228 (01) : 145 - 151
  • [28] Novel Property Cytotoxicity and Mechanism of Food Preservative Brevilaterins against Human Gastric Cancer Cells
    Chen, Zhou
    Hong, Dan
    Li, Siting
    Jia, Yingmin
    FOODS, 2023, 12 (08)
  • [29] Sesquiterpenes from Syneilesis palmata and their cytotoxicity against human cancer cell lines in vitro
    Lee, KH
    Choi, SU
    Lee, KR
    ARCHIVES OF PHARMACAL RESEARCH, 2005, 28 (03) : 280 - 284
  • [30] Minor Valepotriates from Valeriana jatamansi and Their Cytotoxicity against Metastatic Prostate Cancer Cells
    Lin, Sheng
    Fu, Peng
    Chen, Tao
    Ye, Ji
    Su, Yong-Qing
    Yang, Xian-Wen
    Zhang, Zhong-Xiao
    Zhang, Wei-Dong
    PLANTA MEDICA, 2015, 81 (01) : 56 - 61
12345