Cytotoxicity of Meroterpenoids from Sargassum siliquastrum against Human Cancer Cells

被引：0
|
作者：
Lee, Jung Im [1 ]
Kwak, Myoung K. [2 ]
Park, Hee Y. [1 ]
Seo, Youngwan [2 ]
机构：
[1] Natl Fisheries Res & Dev Inst, Food & Safety Res Ctr, Pusan 619705, South Korea
[2] Korea Maritime Univ, Div Marine Environm & Biosci, Pusan 606791, South Korea
来源：
NATURAL PRODUCT COMMUNICATIONS | 2013年 / 8卷 / 04期
关键词：
Sargassum siliquastrum; Chromanol; Cytotoxicity; Human cancer cells; BROWN-ALGA; NATURAL-PRODUCTS; PREVENTION;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The cytotoxicity of the brown alga Sargassum siliquastrum on human cancer cells (AGS, HT-29, HT-1080, and MCF-7) was investigated. Bioassay-guided fractionation of the crude extracts showed that the 85% aq. methanol (MeOH) fraction was the most toxic. Seven known meroterpenoids (1-7) were isolated from this cytotoxic fraction. Each compound was evaluated for its cytotoxic effect on human cancer cells. Compounds 1, 2, and 4 showed strong cytotoxicity against AGS, HT-29, and HT-1080 cell lines, with IC50 values ranging from 0.5 to 5.7 mu g/mL.
引用
收藏
页码：431 / 432
页数：2
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