Bioactive glasses as carriers for bioactive molecules and therapeutic drugs: a review

被引：108
作者：
Hum, Jasmin [1 ]
Boccaccini, Aldo R. [1 ]
机构：
[1] Univ Erlangen Nurnberg, Inst Biomat, D-91058 Erlangen, Germany
来源：
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2012年 / 23卷 / 10期
关键词：
TISSUE ENGINEERING APPLICATIONS; TRICALCIUM-PHOSPHATE COMPOSITE; BONE MORPHOGENETIC PROTEINS; IN-VITRO; DELIVERY-SYSTEM; CONTROLLED-RELEASE; POLYMETHYLMETHACRYLATE BEADS; OSTEOGENIC DIFFERENTIATION; BIOMEDICAL APPLICATIONS; ANTIBACTERIAL ACTIVITY;
D O I：
10.1007/s10856-012-4580-z
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Bioactive glasses (BG) show great promise for bone tissue engineering based on their key properties, e.g., biocompatibility, biodegradability, osteoconductivity as well as osteogenic and angiogenic potential, which make them excellent candidates for bone tissue scaffolds and bone substitute materials. Recent work has shown that dissolution products of bioactive glasses have the potential to induce angiogenesis in addition to their known effect of influencing gene expression and promoting osteoblastic differentiation. One of the most interesting features of BG is their ability to bond both to soft and hard tissues, depending on their composition. To intensify the positive impact of BG for medical applications, there are considerable research efforts on using bioactive glass based platforms as carriers for the encapsulation, delivery and controlled release of bioactive molecules and therapeutic drugs. Different types of bioactive glasses have been considered in combination with different therapeutic drugs, hormones, growth factors and peptides. Using bioactive glasses as drug delivery system combines thus the effectiveness of therapeutic drugs (or bioactive/signaling molecules) with the intrinsic advantages of this inorganic biomaterial. Considering research carried out in the last 15 years, this review presents the different chemical compositions and morphologies of bioactive glasses used as carrier for bioactive molecules and therapeutic drugs and discusses the expanding potential of BG with drug delivery capability focusing in the field of bone tissue engineering.
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页码：2317 / 2333
页数：17
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共 135 条
  • [1] PROTEIN RELEASE KINETICS OF A BIODEGRADABLE IMPLANT FOR FRACTURE NON-UNIONS[J]. AGRAWAL, CM;BEST, J;HECKMAN, JD;BOYAN, BD. BIOMATERIALS, 1995(16)
  • [2] Antibacterial activity of particulate Bioglass® against supra- and subgingival bacteria[J]. Allan, I;Newman, H;Wilson, M. BIOMATERIALS, 2001(12)
  • [3] Drug delivery systems: Entering the mainstream[J]. Allen, TM;Cullis, PR. SCIENCE, 2004(5665)
  • [4] Tetracycline and/or hydrocortisone incorporation and release by bioactive glasses compounds[J]. Andrade, A. L.;Souza, D. M.;Vasconcellos, W. A.;Ferreira, R. V.;Domingues, R. Z. JOURNAL OF NON-CRYSTALLINE SOLIDS, 2009(13)
  • [5] Bioactivity in glass/PMMA composites used as drug delivery system[J]. Arcos, D;Ragel, CV;Vallet-Regí, M. BIOMATERIALS, 2001(07)
  • [6] Sol-gel silica-based biomaterials and bone tissue regeneration[J]. Arcos, Daniel;Vallet-Regi, Maria. ACTA BIOMATERIALIA, 2010(08)
  • [7] ATHANASIOU KA, 1995, CLIN ORTHOP RELAT R, P272
  • [8] Synthesis and characterisation of sol gel derived bioactive glass for biomedical applications[J]. Balamurugan, A.;Sockalingum, G.;Michel, J.;Faure, J.;Banchet, V.;Wortham, L.;Bouthors, S.;Laurent-Maquin, D.;Balossier, G. MATERIALS LETTERS, 2006(29-30)
  • [9] Confinement and controlled release of bisphosphonates on ordered mesoporous silica-based materials[J]. Balas, Francisco;Manzano, Miguel;Horcajada, Patricia;Vallet-Regi, Maria. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006(25)
  • [10] Proliferation, activity, and osteogenic differentiation of bone marrow stromal cells cultured on calcium titanium phosphate microspheres[J]. Barrias, CC;Ribeiro, CC;Lamghari, M;Miranda, CS;Barbosa, MA. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2005(01)
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