PdII and PtII complexes with a thio-aza macrocycle ligand containing an intercalating fragment: Structural and antitumor activity studies

被引:17
作者
Amatori, Stefano [1 ]
Ambrosi, Gianluca [2 ]
Provenzano, Alfredo Errico [1 ]
Fanelli, Mirco [1 ]
Formica, Mauro [2 ]
Fusi, Vieri [2 ]
Giorgi, Luca [2 ]
Macedi, Eleonora [3 ]
Micheloni, Mauro [2 ]
Paoli, Paola [3 ]
Rossi, Patrizia [3 ]
机构
[1] Univ Urbino, Mol Pathol Lab PaoLa, Dept Biomol Sci, I-61032 Fano, PU, Italy
[2] Univ Urbino, Dept Pure & Appl Sci, Via Stn 4, I-61029 Urbino, Italy
[3] Univ Florence, Dept Ind Engn, Via S Marta 3, I-50139 Florence, Italy
关键词
Platinum complexes; Palladium complexes; Macrocyde; Antineoplastic drugs; Cancer; PLATINUM(II) COMPLEXES; IN-VITRO; CRYSTAL-STRUCTURES; DNA-BINDING; PT(II) COMPLEXES; METAL-COMPLEXES; PALLADIUM(II); CYTOTOXICITY; PD(II); CELLS;
D O I
10.1016/j.jinorgbio.2016.06.027
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two new Pt-II and Pd-II complexes of formula [LMCl2] (M = Pt, Pd) were synthesized and characterized both in solution and solid state. They were obtained using the thio-aza macrocycle 9,18-dimethy1-12,17dithia-9,18,27,28-tetraaaza-29-oxatetracyclo[24.2.1.0(2,7).0(20,25)]enneicosa-2,4,6,20,22,24,26,28(1)-octaene (L) containing the 2,5-diphenyl [1, 3, 4joxadiazole as intercalating fragment. M-II is coordinated in cis-position by the two S atoms of L The two crystal structures of [LPtCl2] and [LPdCl2] complexes showed that the M-II ion is located outside the macrocyclic cavity. The square planar coordination sphere is fulfilled by two chloride anions in a cisplatin-like arrangement with the chloride leaving groups exposed to the environment. The biological activity of both [LPtCl2] and [LPdCl2], monitored towards a leukemic cellular model (U937), is coherent with their ability to interfere, at different levels, with the DNA structure. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:154 / 161
页数:8
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