A comparison of gas-liquid chromatography, NMR spectroscopy and Raman spectroscopy for determination of the substituent content of general non-ionic cellulose ethers
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Alvarez-Lorenzo, C
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机构:Univ Santiago de Compostela, Fac Farm, Dept Farm & Tecnol Farmaceut, Santiago De Compostela 15706, Spain
Alvarez-Lorenzo, C
Lorenzo-Ferreira, RA
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机构:Univ Santiago de Compostela, Fac Farm, Dept Farm & Tecnol Farmaceut, Santiago De Compostela 15706, Spain
Lorenzo-Ferreira, RA
Gómez-Amoza, JL
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机构:Univ Santiago de Compostela, Fac Farm, Dept Farm & Tecnol Farmaceut, Santiago De Compostela 15706, Spain
Gómez-Amoza, JL
Martínez-Pacheco, R
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机构:Univ Santiago de Compostela, Fac Farm, Dept Farm & Tecnol Farmaceut, Santiago De Compostela 15706, Spain
Martínez-Pacheco, R
Souto, C
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机构:Univ Santiago de Compostela, Fac Farm, Dept Farm & Tecnol Farmaceut, Santiago De Compostela 15706, Spain
Souto, C
Concheiro, A
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Univ Santiago de Compostela, Fac Farm, Dept Farm & Tecnol Farmaceut, Santiago De Compostela 15706, SpainUniv Santiago de Compostela, Fac Farm, Dept Farm & Tecnol Farmaceut, Santiago De Compostela 15706, Spain
Concheiro, A
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[1] Univ Santiago de Compostela, Fac Farm, Dept Farm & Tecnol Farmaceut, Santiago De Compostela 15706, Spain
[2] Univ Santiago de Compostela, Fac Quim, Dept Quim Analit Nutr & Bromatol, Santiago De Compostela 15706, Spain
This paper describes and compares three techniques that can be used to characterize the substituent content of hydroxypropylcellulose (HPC and L-HPC) and hydroxypropyl methylcellulose (HPMC): gas-liquid chromatography (GLC) with a BP1 column and FI detection, C-13-NMR spectroscopy of hydrolysed samples, and Raman spectroscopy. GLC and C-13-NMR spectroscopy both allow independent quantification of hydroxypropoxyl and methoxyl contents. C-13-NMR spectroscopy, though requiring lengthier sample preparation, has the advantage of also quantifying the degree of substitution at each substitutable glucopyranose hydroxyl. Raman spectroscopy may be useful for rapid approximate estimation of hydroxypropoxyl content. (C) 1999 Elsevier Science B.V. All rights reserved.