Replication of Minute Virus of Mice in Murine Cells Is Facilitated by Virally Induced Depletion of p21

被引：29

作者：

Adeyemi, Richard O. ^{[1
]}

Pintel, David J. ^{[1
]}

机构：

[1] Univ Missouri, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65212 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 15期

关键词：

CYCLIN-DEPENDENT KINASES; DNA-REPLICATION; IN-VITRO; S-PHASE; P53; DEGRADATION; INHIBITOR; ARREST; PCNA; PHOSPHORYLATION;

D O I：

10.1128/JVI.00820-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The DNA damage response to infection with minute virus of mice (MVM) leads to activated p53; however, p21 levels are reduced via a proteasome-mediated mechanism. This loss was sustained, as virus replicated in infected cells held at the G(2)/M border. Addition of the cyclin-dependent kinase (CDK) inhibitor roscovitine after S-phase entry reduced MVM replication, suggesting that CDK activity was critical for continued viral replication and virus-induced reduction of p21 may thus be necessary to prevent inhibition of CDK.

引用

页码：8328 / 8332

页数：5

共 32 条

[21] The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53 [J].

Levine, Arnold J. .

VIROLOGY, 2009, 384 (02) :285-293

[22] Bocavirus Infection Induces a DNA Damage Response That Facilitates Viral DNA Replication and Mediates Cell Death [J].

Luo, Yong ;

Chen, Aaron Yun ;

Qiu, Jianming .

JOURNAL OF VIROLOGY, 2011, 85 (01) :133-145

[23] The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo [J].

Meerbrey, Kristen L. ;

Hu, Guang ;

Kessler, Jessica D. ;

Roarty, Kevin ;

Li, Mamie Z. ;

Fang, Justin E. ;

Herschkowitz, Jason I. ;

Burrows, Anna E. ;

Ciccia, Alberto ;

Sun, Tingting ;

Schmitt, Earlene M. ;

Bernardi, Ronald J. ;

Fu, Xiaoyong ;

Bland, Christopher S. ;

Cooper, Thomas A. ;

Schiff, Rachel ;

Rosen, Jeffrey M. ;

Westbrook, Thomas F. ;

Elledge, Stephen J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (09) :3665-3670

[24] CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2 Pathway during S Phase and after UV Irradiation [J].

Nishitani, Hideo ;

Shiomi, Yasushi ;

Iida, Hiroka ;

Michishita, Masato ;

Takami, Toshihiro ;

Tsurimoto, Toshiki .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (43) :29045-29052

[25] Large T Antigen Promotes JC Virus Replication in G2-arrested Cells by Inducing ATM- and ATR-mediated G2 Checkpoint Signaling [J].

Orba, Yasuko ;

Suzuki, Tadaki ;

Makino, Yoshinori ;

Kubota, Kanako ;

Tanaka, Shinya ;

Kimura, Takashi ;

Sawa, Hirofumi .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (02) :1544-1554

[26] Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM) [J].

Ruiz, Zandra ;

Mihaylov, Ivailo S. ;

Cotmore, Susan F. ;

Tattersall, Peter .

VIROLOGY, 2011, 410 (02) :375-384

[27] DNA damage activates p53 through a phosphorylation-acetylation cascade [J].

Sakaguchi, K ;

Herrera, JE ;

Saito, S ;

Miki, T ;

Bustin, M ;

Vassilev, A ;

Anderson, CW ;

Appella, E .

GENES & DEVELOPMENT, 1998, 12 (18) :2831-2841

[28] p53: Traffic cop at the crossroads of DNA repair and recombination [J].

Sengupta, S ;

Harris, CC .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (01) :44-55

[29] THE P21 INHIBITOR OF CYCLIN-DEPENDENT KINASES CONTROLS DNA-REPLICATION BY INTERACTION WITH PCNA [J].

WAGA, S ;

HANNON, GJ ;

BEACH, D ;

STILLMAN, B .

NATURE, 1994, 369 (6481) :574-578

[30] Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors [J].

Wan, Zhihong ;

Zhi, Ning ;

Wong, Susan ;

Keyvanfar, Keyvan ;

Liu, Delong ;

Raghavachari, Nalini ;

Munson, Peter J. ;

Su, Su ;

Malide, Daniela ;

Kajigaya, Sachiko ;

Young, Neal S. .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (10) :3530-3544

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