Replication of Minute Virus of Mice in Murine Cells Is Facilitated by Virally Induced Depletion of p21

被引：29

作者：

Adeyemi, Richard O. ^{[1
]}

Pintel, David J. ^{[1
]}

机构：

[1] Univ Missouri, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65212 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 15期

关键词：

CYCLIN-DEPENDENT KINASES; DNA-REPLICATION; IN-VITRO; S-PHASE; P53; DEGRADATION; INHIBITOR; ARREST; PCNA; PHOSPHORYLATION;

D O I：

10.1128/JVI.00820-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The DNA damage response to infection with minute virus of mice (MVM) leads to activated p53; however, p21 levels are reduced via a proteasome-mediated mechanism. This loss was sustained, as virus replicated in infected cells held at the G(2)/M border. Addition of the cyclin-dependent kinase (CDK) inhibitor roscovitine after S-phase entry reduced MVM replication, suggesting that CDK activity was critical for continued viral replication and virus-induced reduction of p21 may thus be necessary to prevent inhibition of CDK.

引用

页码：8328 / 8332

页数：5

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