Longitudinal study on enterovirus A71 and coxsackievirus A16 genotype/subgenotype replacements in hand, foot and mouth disease patients in Thailand, 2000-2017

被引:29
作者
Noisumdaeng, Pirom [1 ]
Korkusol, Achareeya [2 ]
Prasertsopon, Jarunee [3 ]
Sangsiriwut, Kantima [4 ]
Chokephaibulkit, Kulkanya [5 ]
Mungaomklang, Anek [6 ]
Thitithanyanont, Arunee [7 ]
Buathong, Rome [8 ]
Guntapong, Ratigorn [9 ]
Puthavathana, Pilaipan [2 ,3 ]
机构
[1] Thammasat Univ, Fac Publ Hlth, Rangsit Ctr, Khlong Luang 12121, Pathum Thani, Thailand
[2] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Microbiol, Bangkok 10700, Thailand
[3] Mahidol Univ, Fac Med Technol, Ctr Res & Innovat, 999 Phuttamonthon 4 Rd, Salaya 73170, Nakhon Pathom, Thailand
[4] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Prevent & Social Med, Bangkok 10700, Thailand
[5] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Pediat, Bangkok 10700, Thailand
[6] Minist Publ Hlth, Debaratana Nakhon Ratchasima Hosp, Nakhon Ratchasima 30280, Thailand
[7] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand
[8] Minist Publ Hlth, Dept Dis Control, Bur Epidemiol, Nonthaburi 11000, Thailand
[9] Minist Publ Hlth, Natl Inst Hlth, Dept Med Sci, Nonthaburi 11000, Thailand
关键词
Hand; foot and mouth disease; Enterovirus A71; Coxsackievirus A16; VP1; sequence; Molecular epidemiology; Genotypic/subgenotypic replacement; MOLECULAR EPIDEMIOLOGY; GENETIC-CHARACTERISTICS; EVOLUTIONARY GENETICS; OUTBREAK; CHILDREN; STRAINS; VP1; YAMAGATA; MALAYSIA; TAIWAN;
D O I
10.1016/j.ijid.2018.12.020
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are the major causative agents of hand, foot and mouth disease (HFMD) worldwide, particularly in the Asia-Pacific region. Several strains have emerged, circulated, and faded out over time in recent decades. This study investigated the EV-A71 and CV-A16 circulating strains and replacement of genotypes/subgenotypes in Thailand during the years 2000-2017. Methods: The complete VP1 regions of 92 enteroviruses obtained from 90 HFMD patients, one asymptomatic adult contact case, and one encephalitic case were sequenced and investigated for serotypes, genotypes, and subgenotypes using a phylogenetic analysis. Results: The 92 enterovirus isolates were identified as 67 (72.8%) EV-A71 strains comprising subgenotypes B4, B5, C1, C2, C4a, C4b and C5, and 25 (27.2%) CV-A16 strains comprising subgenotypes B1a and B1b. Genotypic/subgenotypic replacements were evidenced during the study period. EV-A71 B5 and C4a have been the major circulating strains in Thailand for more than a decade, and CV-A16 B1a has been circulating for almost two decades. Conclusions: This study provides chronological data on the molecular epidemiology of EV-A71 and CV-A16 subgenotypes in Thailand. Subgenotypic replacement frequently occurred with EV-A71, but not CV-A16. Monitoring for viral genetic and subgenotypic changes is important for molecular diagnosis, vaccine selection, and vaccine development. (c) 2019 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:84 / 91
页数:8
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