Anti-inflammatory effect of Pinus sibirica oil extract in animal models

被引：26

作者：

Shikov, Alexander N. ^{[1
]}

Pozharitskaya, Olga N. ^{[1
]}

Makarov, Valery G. ^{[1
]}

Makarova, Marina N. ^{[1
]}

机构：

[1] Interreg Ctr Adaptogen, St Petersburg 195067, Russia

来源：

JOURNAL OF NATURAL MEDICINES | 2008年 / 62卷 / 04期

关键词：

Pinus sibirica; Pinaceae; oil extract; anti-inflammatory activity; rats;

D O I：

10.1007/s11418-008-0254-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The anti-inflammatory effect of the oil extract of seeds of Pinus sibirica Du Tour was evaluated and compared with phenylbutazone. Oral administration of this extract at a dose of 300 mg/kg showed anti-inflammatory activity in the carrageenin-induced edema test in rats. In addition, P. sibirica oil extract showed analgesic properties in the hot-plate test and antipyretic properties in adjuvant-induced local hyperthermia, both in rats. In conclusion, these results provide evidence for the potential usefulness of P. sibirica oil extract, a defined mixture of long-chain polyunsaturated fatty acids, sterols, tocopherols and polyphenols, in inflammatory disorders.

引用

页码：436 / 440

页数：5

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