Formamido-Diterpenes from the South China Sea Sponge Acanthella cavernosa

被引：13

作者：

Xu, Ying ^{[1
,2
]}

Lang, Jun-Hui ^{[2
]}

Jiao, Wei-Hua ^{[2
]}

Wang, Ru-Ping ^{[1
,2
]}

Peng, Ying ^{[1
]}

Song, Shao-Jiang ^{[1
]}

Zhang, Bao-Hua ^{[3
]}

Lin, Hou-Wen ^{[2
]}

机构：

[1] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Second Mil Med Univ, Changzheng Hosp, Dept Pharm, Lab Marine Drugs, Shanghai 200003, Peoples R China

[3] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Shanghai 200438, Peoples R China

来源：

MARINE DRUGS | 2012年 / 10卷 / 07期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

Acanthella cavernosa; formamido-diterpenes; cytotoxicity; antifungal activity; ANTIMALARIAL ACTIVITY; MAGNETIC-RESONANCE; KALIHINOL; POPULATIONS; ISONITRILES; TERPENOIDS;

D O I：

10.3390/md10071445

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven new formamido-diterpenes, cavernenes A-D (1-4), kalihinenes E and F (5-6), and kalihipyran C (7), together with five known compounds (8-12), were isolated from the South China Sea sponge Acanthella cavernosa. Structures were established using IR, HRESIMS, 1D and 2D NMR, and single X-ray diffraction techniques. The isolated compounds were assessed for their cytotoxicity against a small panel of human cancer cell lines (HCT-116, A549, HeLa, QGY-7701, and MDA-MB-231) with IC50 values in the range of 6-18 mu M. In addition, compound 9 showed weak antifungal activity against Trichophyton rubrum and Microsporum gypseum with MIC values of 8 and 32 mu g/mL, respectively, compound 10 displayed weak antifungal activity against fungi Candida albicans, Cryptococcus neoformans, T. rubrum, and M. gypseum with MIC values of 8, 8, 4, and 8 mu g/mL, respectively.

引用

页码：1445 / 1458

页数：14

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