Protection against Radiotherapy-Induced Toxicity

被引：74

作者：

Hall, Susan ^{[1
,2
]}

Rudrawar, Santosh ^{[1
,2
]}

Zunk, Matthew ^{[1
,2
]}

Bernaitis, Nijole ^{[1
,2
]}

Arora, Devinder ^{[1
,2
]}

McDermott, CatherineM ^{[3
]}

Anoopkumar-Dukie, Shailendra ^{[1
,2
]}

机构：

[1] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast 4222, Australia

[2] Griffith Univ, Sch Pharm, Gold Coast 4222, Australia

[3] Bond Univ, Fac Hlth Sci & Med, Ctr Urol Res, Robina 4226, Australia

来源：

ANTIOXIDANTS | 2016年 / 5卷 / 03期

关键词：

radiotherapy; toxicity; oxidative stress; inflammation; INDUCED DNA-DAMAGE; RADIATION-INDUCED LUNG; ACUTE GASTROINTESTINAL COMPLICATIONS; INDUCED ORAL MUCOSITIS; TUMOR-NECROSIS-FACTOR; GROWTH-FACTOR-BETA; IONIZING-RADIATION; DOUBLE-BLIND; LIPID-PEROXIDATION; GAMMA-TOCOTRIENOL;

D O I：

10.3390/antiox5030022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Radiation therapy is a highly utilized therapy in the treatment of malignancies with up to 60% of cancer patients receiving radiation therapy as a part of their treatment regimen. Radiation therapy does, however, cause a wide range of adverse effects that can be severe and cause permanent damage to the patient. In an attempt to minimize these effects, a small number of compounds have been identified and are in use clinically for the prevention and treatment of radiation associated toxicities. Furthermore, there are a number of emerging therapies being developed for use as agents that protect against radiation-induced toxicities. The aim of this review was to evaluate and summarise the evidence that exists for both the known radioprotectant agents and the agents that show promise as future radioprotectant agents.

引用

页数：18

共 132 条

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