Protection against Radiotherapy-Induced Toxicity

被引:74
作者
Hall, Susan [1 ,2 ]
Rudrawar, Santosh [1 ,2 ]
Zunk, Matthew [1 ,2 ]
Bernaitis, Nijole [1 ,2 ]
Arora, Devinder [1 ,2 ]
McDermott, CatherineM [3 ]
Anoopkumar-Dukie, Shailendra [1 ,2 ]
机构
[1] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast 4222, Australia
[2] Griffith Univ, Sch Pharm, Gold Coast 4222, Australia
[3] Bond Univ, Fac Hlth Sci & Med, Ctr Urol Res, Robina 4226, Australia
关键词
radiotherapy; toxicity; oxidative stress; inflammation; INDUCED DNA-DAMAGE; RADIATION-INDUCED LUNG; ACUTE GASTROINTESTINAL COMPLICATIONS; INDUCED ORAL MUCOSITIS; TUMOR-NECROSIS-FACTOR; GROWTH-FACTOR-BETA; IONIZING-RADIATION; DOUBLE-BLIND; LIPID-PEROXIDATION; GAMMA-TOCOTRIENOL;
D O I
10.3390/antiox5030022
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Radiation therapy is a highly utilized therapy in the treatment of malignancies with up to 60% of cancer patients receiving radiation therapy as a part of their treatment regimen. Radiation therapy does, however, cause a wide range of adverse effects that can be severe and cause permanent damage to the patient. In an attempt to minimize these effects, a small number of compounds have been identified and are in use clinically for the prevention and treatment of radiation associated toxicities. Furthermore, there are a number of emerging therapies being developed for use as agents that protect against radiation-induced toxicities. The aim of this review was to evaluate and summarise the evidence that exists for both the known radioprotectant agents and the agents that show promise as future radioprotectant agents.
引用
收藏
页数:18
相关论文
共 132 条
[1]   Radiation-associated cardiovascular disease: Manifestations and management [J].
Adams, MJ ;
Lipshultz, SE ;
Schwartz, C ;
Fajardo, LF ;
Coen, V ;
Constine, LS .
SEMINARS IN RADIATION ONCOLOGY, 2003, 13 (03) :346-356
[2]   In vitro studies on radioprotective efficacy of silymarin against γ-irradiation [J].
Adhikari, Manish ;
Dhaker, Atlar ;
Adhikari, Jawahar ;
Ivanov, Veselin ;
Singh, Vijay ;
Chawla, Raman ;
Kumar, Raj ;
Sharma, Rakesh ;
Karamalakova, Yana ;
Gadjeva, Veselina ;
Arora, Rajesh .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2013, 89 (03) :200-211
[3]   Soy Isoflavones in Conjunction With Radiation Therapy in Patients With Prostate Cancer [J].
Ahmad, Iftekhar U. ;
Forman, Jeffrey D. ;
Sarkar, Fazlul H. ;
Hillman, Gilda G. ;
Heath, Elisabeth ;
Vaishampayan, Ulka ;
Cher, Michael L. ;
Andic, Fundagul ;
Rossi, Peter J. ;
Kucuk, Omer .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2010, 62 (07) :996-1000
[4]   THE ANTIINFLAMMATORY MOIETY OF SULFASALAZINE, 5-AMINOSALICYLIC ACID, IS A RADICAL SCAVENGER [J].
AHNFELTRONNE, I ;
NIELSEN, OH .
AGENTS AND ACTIONS, 1987, 21 (1-2) :191-194
[5]   Can Angiotensin-Converting Enzyme Inhibitors Reduce the Incidence, Severity, and Duration of Radiation Proctitis? [J].
Alashkham, Abduelmenem ;
Paterson, Catherine ;
Rauchhaus, Petra ;
Nabi, Ghulam .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2016, 94 (01) :93-101
[6]   Lycopene in the Prevention of Gastrointestinal Toxicity of Radiotherapy [J].
Andic, Fundagul ;
Garipagaoglu, Melahat ;
Yurdakonar, Ebru ;
Tuncel, Nina ;
Kucuk, Omer .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2009, 61 (06) :784-788
[7]  
[Anonymous], 1990, HLTH EFFECTS EXPOSUR, DOI DOI 10.17226/1224
[8]   Radical mediators and mitogen-activated protein kinase signaling in oxygen-dependent radio sensitivity of human tumor cell lines [J].
Anoopkumar-Dukie, S ;
Conere, T ;
Carey, JB ;
Allshire, A .
FREE RADICAL BIOLOGY AND MEDICINE, 2005, 39 (02) :188-194
[9]   Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer [J].
Antonadou, D ;
Pepelassi, M ;
Synodinou, M ;
Puglisi, M ;
Throuvalas, N .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2002, 52 (03) :739-747
[10]   Can phytochemicals be a bridge to develop new radioprotective agents? [J].
Aprotosoaie, Ana Clara ;
Trifan, Adriana ;
Gille, Elvira ;
Petreus, Tudor ;
Bordeianu, Gabriela ;
Miron, Anca .
PHYTOCHEMISTRY REVIEWS, 2015, 14 (04) :555-566