Synthesis and reactions of the pestalotiopsin skeleton

被引：37

作者：

Baker, Thomas M. ^{[1
]}

Edmonds, David J. ^{[2
]}

Hamilton, Deborah ^{[1
]}

O'Brien, Christopher J. ^{[2
]}

Procter, David J. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

[2] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 30期

关键词：

natural products; pestalotiopsins; samarium; taedolidols; total synthesis;

D O I：

10.1002/anie.200801900

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Family ties: The pestalotiopsin framework has been constructed by using a SmI2-mediated cyclization and a Nozaki-Hiyama-Kishi coupling to construct the four- and nine-membered rings of the target, respectively. The first synthetic entry into the previously unexplored taedolidol family of natural products has been achieved through a stereoselective, acid-mediated cyclization of the pestalotiopsin skeleton. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5631 / 5633

页数：3

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