Clinical Neuropathology practice news 2-2014: ATRX, a new candidate biomarker in gliomas

被引：20

作者：

Haberler, Christine ^{[1
]}

Woehrer, Adelheid ^{[1
]}

机构：

[1] Med Univ Vienna, Inst Neurol, A-1097 Vienna, Austria

来源：

CLINICAL NEUROPATHOLOGY | 2014年 / 33卷 / 02期

关键词：

gliomas; genomic; aberrations; molecular biomarker; ATRX; IDH; 1p/19q; ASTROCYTIC TUMORS; FREQUENT ATRX; HISTONE H3.3; MUTATIONS; CLASSIFICATION; GLIOBLASTOMA; SUBGROUPS;

D O I：

10.5414/NP300758

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Genome-wide molecular approaches have substantially elucidated molecular alterations and pathways involved in the oncogenesis of brain tumors. In gliomas, several molecular biomarkers including IDH mutation, 1p/19q co-deletion, and MGMT promotor methylation status have been introduced into neuropathological practice. Recently, mutations of the ATRX gene have been found in various subtypes and grades of gliomas and were shown to refine the prognosis of malignant gliomas in combination with IDH and 1p/19q status. Mutations of ATRX are associated with loss of nuclear ATRX protein expression, detectable by a commercially available antibody, thus turning ATRX into a promising prognostic candidate biomarker in the routine neuropathological setting.

引用

页码：108 / 111

页数：4

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