Tyrosine Kinase Inhibitor Therapy Induces Remission in a Patient With Refractory EBF1-PDGFRB-Positive Acute Lymphoblastic Leukemia

被引：171
作者：
Weston, Brent W. [1 ]
Hayden, Melissa A. [2 ]
Roberts, Kathryn G. [3 ]
Bowyer, Susan [2 ]
Hsu, Johann [1 ]
Fedoriw, George [1 ]
Rao, Kathleen W. [1 ]
Mullighan, Charles G. [3 ]
机构：
[1] Univ N Carolina, Chapel Hill, NC 27514 USA
[2] Univ North Carolina Hosp, McLendon Clin Labs, Chapel Hill, NC USA
[3] St Jude Childrens Res Hosp, Memphis, TN 38105 USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2013年 / 31卷 / 25期
关键词：
GROWTH-FACTOR RECEPTOR; MYELOPROLIFERATIVE DISORDERS; IMATINIB MESYLATE; B-PROGENITOR; REARRANGEMENT; FUSION; BETA; ACTIVATION; RESPONSES; IKZF1;
D O I：
10.1200/JCO.2012.47.6770
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：E413 / E416
页数：4
相关论文
共 17 条
  • [1] Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
    Apperley, JF
    Gardembas, M
    Melo, JV
    Russell-Jones, R
    Bain, BJ
    Baxter, J
    Chase, A
    Chessells, JM
    Colombat, M
    Dearden, CE
    Dimitrijevic, S
    Mahon, FX
    Marin, D
    Nikolova, Z
    Olavarria, E
    Silberman, S
    Schultheis, B
    Cross, NCP
    Goldman, JM
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (07) : 481 - 487
  • [2] The TEL platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways
    Carroll, M
    Tomasson, MH
    Barker, GF
    Golub, TR
    Gilliland, DG
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) : 14845 - 14850
  • [3] A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
    Cools, J
    DeAngelo, DJ
    Gotlib, J
    Stover, EH
    Legare, RD
    Cortes, J
    Kutok, J
    Clark, J
    Galinsky, I
    Griffin, JD
    Cross, NCP
    Tefferi, A
    Malone, J
    Alam, R
    Schrier, SL
    Schmid, J
    Rose, M
    Vandenberghe, P
    Verhoef, G
    Boogaerts, M
    Wlodarska, I
    Kantarjian, H
    Marynen, P
    Coutre, SE
    Stone, R
    Gilliland, DG
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (13) : 1201 - 1214
  • [4] Philadelphia Chromosome-Negative Myeloproliferative Neoplasm With a Novel Platelet-Derived Growth Factor Receptor-β Rearrangement Responsive to Imatinib
    Cornfield, Dennis
    Shah, Usman
    Cross, Nicholas
    Bennett, Courtney
    Sun, Guoxian
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (09) : E109 - E111
  • [5] Fibroblast growth factor receptor and platelet-derived growth factor receptor abnormalities in eosinophilic myeloproliferative disorders
    Cross, Nicholas C. P.
    Reiter, Andreas
    [J]. ACTA HAEMATOLOGICA, 2008, 119 (04) : 199 - 206
  • [6] Durable responses to imatinib in patients with PDGFRB fusion gene-positive and BCR-ABL-negative chronic myeloproliferative disorders
    David, Marianna
    Cross, Nicholas C. P.
    Burgstaller, Sonja
    Chase, Andrew
    Curtis, Claire
    Dang, Raymond
    Gardembas, Martine
    Goldman, John M.
    Grand, Francis
    Hughes, George
    Huguet, Francoise
    Lavender, Louise
    McArthur, Grant A.
    Mahon, Francois X.
    Massimini, Giorgio
    Melo, Junia
    Rousselot, Philippe
    Russell-Jones, Robin J.
    Seymour, John F.
    Smith, Graeme
    Stark, Alastair
    Waghorn, Katherine
    Nikolova, Zariana
    Apperley, Jane F.
    [J]. BLOOD, 2007, 109 (01) : 61 - 64
  • [7] A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study
    Den Boer, Monique L.
    van Slegtenhorst, Marjon
    De Menezes, Renee X.
    Cheok, Meyling H.
    Buijs-Gladdines, Jessica G. C. A. M.
    Peters, Susan T. C. J. M.
    Van Zutven, Laura C. M.
    Beverloo, H. Berna
    Van der Spek, Peter J.
    Escherich, Gaby
    Horstmann, Martin A.
    Janka-Schoub, Gritta E.
    Kamps, Willem A.
    Evans, William E.
    Pieters, Rob
    [J]. LANCET ONCOLOGY, 2009, 10 (02) : 125 - 134
  • [8] EBF CONTAINS A NOVEL ZINC COORDINATION MOTIF AND MULTIPLE DIMERIZATION AND TRANSCRIPTIONAL ACTIVATION DOMAINS
    HAGMAN, J
    GUTCH, MJ
    LIN, HS
    GROSSCHEDL, R
    [J]. EMBO JOURNAL, 1995, 14 (12) : 2907 - 2916
  • [9] Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia
    Harvey, Richard C.
    Mullighan, Charles G.
    Chen, I-Ming
    Wharton, Walker
    Mikhail, Fady M.
    Carroll, Andrew J.
    Kang, Huining
    Liu, Wei
    Dobbin, Kevin K.
    Smith, Malcolm A.
    Carroll, William L.
    Devidas, Meenakshi
    Bowman, W. Paul
    Camitta, Bruce M.
    Reaman, Gregory H.
    Hunger, Stephen P.
    Downing, James R.
    Willman, Cheryl L.
    [J]. BLOOD, 2010, 115 (26) : 5312 - 5321
  • [10] Low-dose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in FIP1L1-PDGFRA-positive chronic eosinophilic leukemia
    Jovanovic, Jelena V.
    Score, Joannah
    Waghorn, Katherine
    Cilloni, Daniela
    Gottardi, Enrico
    Metzgeroth, Georgia
    Erben, Philipp
    Popp, Helena
    Walz, Christoph
    Hochhaus, Andreas
    Roche-Lestienne, Catherine
    Preudhomme, Claude
    Solomon, Ellen
    Apperley, Jane
    Rondoni, Michela
    Ottaviani, Emanuela
    Martinelli, Giovanni
    Brito-Babapulle, Finella
    Saglio, Giuseppe
    Hehlmann, Ruediger
    Cross, Nicholas C. P.
    Reiter, Andreas
    Grimwade, David
    [J]. BLOOD, 2007, 109 (11) : 4635 - 4640
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