Synthesis of heterocycle substituted 1-aryl-4-piperidones

被引:15
作者
Hu, BH [1 ]
Malamas, M [1 ]
Ellingboe, J [1 ]
机构
[1] Wyeth Res, Chem Sci, Collegeville, PA 19426 USA
关键词
D O I
10.3987/COM-02-9447
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A series of heterocycle substituted 1-aryl-4-piperidones were prepared via Knoevenagel condensations between nitrogen-containing 5-membered heterocycles and benzaldehyde (1) followed by reduction or amination. The oxadiazolidinedione ring was formed by reacting the N-hydroxyurea (10) with methyl chloroformate and sodium hydride.
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页码:857 / 870
页数:14
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