Synthesis and biological evaluation of coumarincarboxylic acids as inhibitors of gyrase B. L-rhamnose as an effective substitute for L-noviose

被引：46

作者：

Ferroud, D

Collard, J

Klich, M

Dupuis-Hamelin, C

Mauvais, P

Lassaigne, P

Bonnefoy, A

Musicki, B

机构：

[1] Hoechst Marion Roussel, Med Chem, F-93235 Romainville, France

[2] Hoechst Marion Roussel, Infect Dis, F-93235 Romainville, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(99)00493-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novobiocin-like coumarincarboxylic acids has been prepared bearing the L-rhamnosyl moiety as the sugar portion of the molecule. The similar DNA gyrase inhibitory activity of the novel class of coumarins to that of novobiocin demonstrates that L-rhamnose can effectively replace L-noviose. Introduction of alkyl side-chains at C-5 of coumarin leads to improved in vitro antibacterial properties in the novel series. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2881 / 2886

页数：6

共 27 条

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