Multi-stage analysis of gene expression and transcription regulation in C57/B6 mouse liver development

被引：62
作者：
Li, Tingting [1 ,2 ]
Huang, Jian [3 ]
Jiang, Ying [4 ]
Zeng, Yan [4 ]
He, Fuchu [4 ,5 ]
Zhang, Michael Q. [1 ,2 ,6 ]
Han, Zeguang [3 ]
Zhang, Xuegong [1 ,2 ]
机构：
[1] Tsinghua Univ, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China
[2] Tsinghua Univ, Bioinformat Div, TNLIST Dept Automat, Beijing 100084, Peoples R China
[3] Chinese Natl Human Genome Ctr Shanghai, Shanghai 201203, Peoples R China
[4] Beijing Inst Radiat Med, Beijing Proteome Res Ctr, State Key Lab Proteom, Beijing 102206, Peoples R China
[5] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China
[6] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
来源：
GENOMICS | 2009年 / 93卷 / 03期
关键词：
Liver development; Microarray; Gene expression; Function; Transcriptional regulation; PREMATURE MICE; DEFINITIONS; PATTERNS; BIRTH;
D O I：
10.1016/j.ygeno.2008.10.006
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The liver performs a number of essential functions for life. The development of such a Complex Organ relies on finely regulated gene expression profiles which change over time in the development and determine the phenotype and function of the liver. We used high-density oligonucleotide microarrays to study the gene expression and transcription regulation at 14 time points across the C57/B6 mouse liver development, which include E11.5 (embryonic day 11.5), E12.5, E13.5, E14.5, E15.5, E16.5, E17.5, E18.5, Day0 (the day of birth), Day3, Day7, Day14, Day21, and normal adult liver. With these data, we made a comprehensive analysis on gene expression patterns, functional preferences and transcriptional regulations during the liver development. A group of uncharacterized genes which might be involved in the fetal hematopoiesis were detected. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：235 / 242
页数：8
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