共 219 条
Shaping Synapses by the Neural Extracellular Matrix
被引:115
作者:
Ferrer-Ferrer, Maura
[1
]
Dityatev, Alexander
[1
,2
,3
]
机构:
[1] German Ctr Neurodegenerat Dis DZNE, Mol Neuroplast, Magdeburg, Germany
[2] CBBS, Magdeburg, Germany
[3] Otto von Guericke Univ, Med Fac, Magdeburg, Germany
来源:
FRONTIERS IN NEUROANATOMY
|
2018年
/
12卷
关键词:
perineuronal net;
synaptogenesis;
synaptic plasticity;
proteolysis;
disease;
LONG-TERM POTENTIATION;
HIPPOCAMPAL SYNAPTIC PLASTICITY;
ASTROCYTE-SECRETED PROTEINS;
DENDRITIC SPINE DEVELOPMENT;
NMDA RECEPTOR;
NEURONAL PENTRAXIN;
MICE DEFICIENT;
POSTSYNAPTIC MATURATION;
EXCITATORY SYNAPSES;
TENASCIN-C;
D O I:
10.3389/fnana.2018.00040
中图分类号:
R602 [外科病理学、解剖学];
R32 [人体形态学];
学科分类号:
100101 ;
摘要:
Accumulating data support the importance of interactions between pre- and postsynaptic neuronal elements with astroglial processes and extracellular matrix (ECM) for formation and plasticity of chemical synapses, and thus validate the concept of a tetrapartite synapse. Here we outline the major mechanisms driving: (i) synaptogenesis by secreted extracellular scaffolding molecules, like thrombospondins (TSPs), neuronal pentraxins (NPs) and cerebellins, which respectively promote presynaptic, postsynaptic differentiation or both; (ii) maturation of synapses via reelin and integrin ligands-mediated signaling; and (iii) regulation of synaptic plasticity by ECM-dependent control of induction and consolidation of new synaptic configurations. Particularly, we focused on potential importance of activity-dependent concerted activation of multiple extracellular proteases, such as ADAMTS4/5/15, MMP9 and neurotrypsin, for permissive and instructive events in synaptic remodeling through localized degradation of perisynaptic ECM and generation of proteolytic fragments as inducers of synaptic plasticity.
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页数:16
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