Robotically assisted laparoscopic radical prostatectomy induces lower tissue trauma than radical retropubic prostatectomy

被引:1
作者
Quinto, Denise [1 ]
Reis, Sabrina T. [2 ,3 ]
Zampolli, Lucca Juvele [2 ]
Pimenta, Ruan [2 ]
Guimaraes, Vanessa R. [2 ]
Viana, Nayara I. [2 ]
dos Santos, Gabriel A. [2 ]
Gimenez, Mario P. [1 ]
Leite, Katia R. [2 ]
Zampolli, Hamilton [1 ]
da Cruz, Jose Arnaldo S. [1 ]
Srougi, Miguel [2 ]
Passerotti, Carlo C. [1 ,2 ]
机构
[1] Hosp Alemao Oswaldo Cruz, Ctr Robot Surg, BR-01327001 Sao Paulo, Brazil
[2] Univ Sao Paulo FMUSP, Fac Med, Urol Dept, Lab Med Invest LIM55, Av Dr Arnaldo 455,2 Andar,Sala 2141, BR-01246903 Sao Paulo, SP, Brazil
[3] Fac Atenas, Campus Passos, BR-37900380 Passos, Brazil
关键词
Prostate cancer; Surgery; Cytokines; TNF; MEDIATORS; RESPONSES; STRESS;
D O I
10.1007/s11701-020-01150-y
中图分类号
R61 [外科手术学];
学科分类号
摘要
To compare tissue trauma between Retropubic Radical Prostatectomy and Robotically Assisted Laparoscopic Radical Prostatectomy by inflammatory mediators. Serum samples from 40 patients submitted to RALP and 20 patients submitted to RRP were withdrawn at four different time points. The cytokines IL-4, IL-8, IL-6, IL-1B, IL-10 and TNF-alpha were detected using ELISA/Multiplex assays and xMAP-Luminex (R). With both techniques, IL-10 and IL-6 were higher in T4 than in T1-T3 (p = 0.001). IL-10 and IL-6 were higher in T4 in open surgery than in robotic surgery (p = 0.000 andp = 0.001, respectively). Compared with both groups, IL-6 and IL-10 were higher in T4 in open surgery than in robotic surgery. Thus, we can postulate that RALP causes less tissue trauma than classical RRP, as indicated by the more limited increase in inflammatory mediators such as IL-6 and IL-10.
引用
收藏
页码:147 / 151
页数:5
相关论文
共 13 条
[1]   Cell response to surgery [J].
Choileain, Niamh Ni ;
Redmond, H. Paul .
ARCHIVES OF SURGERY, 2006, 141 (11) :1132-1140
[2]   The immunornodulatory effects of Laparoscopic surgery [J].
Corrigan, Mark ;
Cahill, Ronan A. ;
Redmond, Henry Paul .
SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES, 2007, 17 (04) :256-261
[3]   Is robotically assisted laparoscopic radical prostatectomy less invasive than retropubic radical prostatectomy? Results from a prospective, unrandomized, comparative study [J].
Fracalanza, Simonetta ;
Ficarra, Vincenzo ;
Cavalleri, Stefano ;
Galfano, Antonio ;
Novara, Giacomo ;
Mangano, Angelo ;
Plebani, Mario ;
Artibani, Walter .
BJU INTERNATIONAL, 2008, 101 (09) :1145-1149
[4]   Mechanisms of disease: Acute-phase proteins and other systemic responses to inflammation [J].
Gabay, C ;
Kushner, I .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (06) :448-454
[5]   Peritoneal acidosis mediates immunoprotection in laparoscopic surgery [J].
Hanly, Eric J. ;
Aurora, Alexander A. ;
Shih, Samuel P. ;
Fuentes, Joseph M. ;
Marohn, Michael R. ;
De Maio, Antonio ;
Talamini, Mark A. .
SURGERY, 2007, 142 (03) :357-364
[6]  
Heidenreich A, 2008, EUR UROL, V53, P68, DOI 10.1016/j.eururo.2007.09.002
[7]   Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway [J].
Heinrich, PC ;
Behrmann, I ;
Müller-Newen, G ;
Schaper, F ;
Graeve, L .
BIOCHEMICAL JOURNAL, 1998, 334 :297-314
[8]  
Jess P, 2000, EUR J SURG, V166, P540
[9]   Prospective non-randomized evaluation of four mediators of the systemic response after extraperitoneal laparoscopic and open retropubic radical prostatectomy [J].
Jurczok, Andreas ;
Zacharias, Mario ;
Wagner, Sigrid ;
Hamza, Amir ;
Fornara, Paolo .
BJU INTERNATIONAL, 2007, 99 (06) :1461-1466
[10]  
Karayiannakis AJ, 1997, BRIT J SURG, V84, P467