Diffusivity signatures characterize trigeminal neuralgia associated with multiple sclerosis

被引:46
作者
Chen, David Q. [1 ,2 ,3 ]
DeSouza, Danielle D. [1 ,2 ,3 ]
Hayes, David J. [1 ]
Davis, Karen D. [1 ,2 ,3 ]
O'Connor, Paul [5 ]
Hodaie, Mojgan [1 ,2 ,3 ,4 ]
机构
[1] Univ Hlth Network, Toronto Western Res Inst, Div Brain Imaging & Behav Syst Neurosci, Toronto, ON, Canada
[2] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[3] Univ Toronto, Dept Surg, Toronto, ON, Canada
[4] Toronto Western Hosp, Dept Surg, Div Neurosurg, Toronto, ON M5T 2S8, Canada
[5] Univ Toronto, St Michaels Hosp, Div Neurol, Toronto, ON M5S 1A1, Canada
关键词
Multiple sclerosis; pain; trigeminal neuralgia; diffusion tensor imaging; high angular resolution diffusion imaging; tractography; magnetic resonance imaging; structural; brain; microstructural; WHITE-MATTER DAMAGE; RADIAL DIFFUSIVITY; CORPUS-CALLOSUM; AXONAL INJURY; SPINAL-CORD; MOUSE MODEL; TENSOR; DEMYELINATION; TRACTOGRAPHY; PAIN;
D O I
10.1177/1352458515579440
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Trigeminal neuralgia secondary to multiple sclerosis (MS-TN) is a facial neuropathic pain syndrome similar to classic trigeminal neuralgia (TN). While TN is caused by neurovascular compression of the fifth cranial nerve (CN V), how MS-related demyelination correlates with pain in MS-TN is not understood. Objectives: We aim to examine diffusivities along CN V in MS-TN, TN, and controls in order to reveal differential neuroimaging correlates across groups. Methods: 3T MR diffusion weighted, T1, T2 and FLAIR sequences were acquired for MS-TN, TN, and controls. Multi-tensor tractography was used to delineate CN V across cisternal, root entry zone (REZ), pontine and peri-lesional segments. Diffusion metrics including fractional anisotropy (FA), and radial (RD), axial (AD), and mean diffusivities (MD) were measured from each segment. Results: CN V segments showed distinctive diffusivity patterns. The TN group showed higher FA in the cisternal segment ipsilateral to the side of pain, and lower FA in the ipsilateral REZ segment. The MS-TN group showed lower FA in the ipsilateral peri-lesional segments, suggesting differential microstructural changes along CN V in these conditions. Conclusions: The study demonstrates objective differences in CN V microstrucuture in TN and MS-TN using non-invasive neuroimaging. This represents a significant improvement in the methods currently available to study pain in MS.
引用
收藏
页码:51 / 63
页数:13
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