A Review of DNA Methylation and microRNA Expression in Recurrent Pediatric Acute Leukemia

被引：19

作者：

Hale, Victoria ^{[1
]}

Hale, Gregory A. ^{[1
,2
,3
]}

Brown, Patrick A. ^{[2
,3
]}

Amankwah, Ernest K. ^{[1
,2
]}

机构：

[1] Johns Hopkins All Childrens Hosp, 501 6th Ave South, St Petersburg, FL 33701 USA

[2] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

来源：

ONCOLOGY | 2017年 / 92卷 / 02期

关键词：

Pediatric leukemia; Epigenetics; Methylation; microRNA; Recurrence; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; MINIMAL RESIDUAL DISEASE; POOR-PROGNOSIS; EPIGENETIC THERAPY; UP-REGULATION; CHILDHOOD; RELAPSE; CANCER; GENE;

D O I：

10.1159/000452091

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute leukemia is the most common childhood cancer diagnosis and leading cause of cancer-related death among children and adolescents. Despite substantial improvements in the survival rate of childhood acute leukemia, approximately 20-40% of the patients who undergo treatment develop relapse, with a dismal one third of these patients surviving in the long term. Epigenetics plays an important role in the progression of cancer, and existing evidence suggests a role in childhood acute leukemia relapse. A better understanding of the epigenetic mechanisms in recurrent acute leukemia could potentially lead to novel therapeutic regimens to prevent or treat disease recurrences. In this review, we summarize existing evidence on two of the most studied epigenetic mechanisms, DNA methylation and microRNA expression, in recurrent pediatric acute leukemia. (C) 2016 S. Karger AG, Basel

引用

页码：61 / 67

页数：7

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