Review of transplantation of neural stem/progenitor cells for spinal cord injury

被引：150
作者：
Mothe, Andrea J. [1 ,2 ,3 ]
Tator, Charles H. [1 ,2 ,3 ,4 ]
机构：
[1] Toronto Western Res Inst, Krembil Neurosci Ctr, Toronto, ON M5T 2S8, Canada
[2] Toronto Western Hosp, Univ Hlth Network, Toronto, ON M5T 2S8, Canada
[3] Univ Toronto, Toronto, ON M5T 2S8, Canada
[4] Univ Toronto, Dept Surg, Div Neurosurg, Toronto, ON M5S 3E1, Canada
来源：
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2013年 / 31卷 / 07期
关键词：
Spinal cord injury; Neural stem cells; Transplantation; EMBRYONIC STEM-CELLS; CENTRAL-NERVOUS-SYSTEM; RESTRICTED PRECURSOR CELLS; ADULT MAMMALIAN FOREBRAIN; PROGENITOR CELLS; FUNCTIONAL RECOVERY; GROWTH-FACTORS; HUMAN BRAIN; IN-VITRO; CLINICAL-TRIALS;
D O I：
10.1016/j.ijdevneu.2013.07.004
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Spinal cord injury (SCI) is a debilitating condition often resulting in paralysis, yet currently there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy for promoting tissue repair after SCI. Stem cells offer a renewable source of cells with inherent plasticity for tissue regeneration. Neural stem/progenitor cells (NSPCs) are multipotent cells that self-renew and are committed to the neural lineage, and thus, they are especially suited to SCI repair. NSPCs may differentiate into neural cells after transplantation into the injured spinal cord, replacing lost or damaged cells, providing trophic support, restoring connectivity, and facilitating regeneration. Here, we review experimental studies and considerations for clinical translation of NSPC transplantation for SCI. (C) 2013 ISDN. Published by Elsevier Ltd. All rights reserved.
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收藏
页码：701 / 713
页数：13
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