Oxygen sensing, HIF-1α stabilization and potential therapeutic strategies

被引:61
作者
Hofer, T
Wenger, RH
Gassmann, M [1 ]
机构
[1] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland
[2] Univ Zurich, Inst Vet Physiol, CH-8057 Zurich, Switzerland
[3] Med Univ Lubeck, Inst Physiol, D-23538 Lubeck, Germany
来源
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2002年 / 443卷 / 04期
关键词
MAP kinase; prolyl hydroxylase; pVHL; therapeutic angiogenesis; VEGF;
D O I
10.1007/s00424-001-0759-8
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
[No abstract available]
引用
收藏
页码:503 / 507
页数:5
相关论文
共 35 条
[1]  
Blancher C, 2001, CANCER RES, V61, P7349
[2]   A conserved family of prolyl-4-hydroxylases that modify HIF [J].
Bruick, RK ;
McKnight, SL .
SCIENCE, 2001, 294 (5545) :1337-1340
[3]   Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression [J].
Camenisch, G ;
Stroka, DM ;
Gassmann, M ;
Wenger, RH .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2001, 443 (02) :240-249
[4]  
Chen EY, 2001, CANCER RES, V61, P2429
[5]  
Chilov D, 1999, J CELL SCI, V112, P1203
[6]   Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein [J].
Cockman, ME ;
Masson, N ;
Mole, DR ;
Jaakkola, P ;
Chang, GW ;
Clifford, SC ;
Maher, ER ;
Pugh, CW ;
Ratcliffe, PJ ;
Maxwell, PH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (33) :25733-25741
[7]   Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α [J].
Elson, DA ;
Thurston, G ;
Huang, LE ;
Ginzinger, DG ;
McDonald, DM ;
Johnson, RS ;
Arbeit, JM .
GENES & DEVELOPMENT, 2001, 15 (19) :2520-2532
[8]   C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation [J].
Epstein, ACR ;
Gleadle, JM ;
McNeill, LA ;
Hewitson, KS ;
O'Rourke, J ;
Mole, DR ;
Mukherji, M ;
Metzen, E ;
Wilson, MI ;
Dhanda, A ;
Tian, YM ;
Masson, N ;
Hamilton, DL ;
Jaakkola, P ;
Barstead, R ;
Hodgkin, J ;
Maxwell, PH ;
Pugh, CW ;
Schofield, CJ ;
Ratcliffe, PJ .
CELL, 2001, 107 (01) :43-54
[9]  
HOFER T, 2001, FASEB J, DOI DOI 10.1096/F4.01-0546F4E
[10]   Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway [J].
Huang, LE ;
Gu, J ;
Schau, M ;
Bunn, HF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) :7987-7992