Genetic polymorphism in association with susceptibility to tuberculosis: a study in a Pakistani population

被引：5
作者：
Naz, AsmaGul [1 ]
Aslam, Muhammad Assad [1 ]
Khan, Abrar Ul Haq [2 ]
Rasul, Sumaira [1 ]
Manzoor, Hamid [1 ]
Iqbal, Rehana [3 ]
Shehzad, Ahmed [4 ]
Ali, Muhammad [5 ]
机构：
[1] Bahauddin Zakariya Univ, Inst Mol Biol & Biotechnol, Multan, Pakistan
[2] Univ Agr Faisalabad, Inst Microbiol, Faisalabad, Pakistan
[3] Bahauddin Zakariya Univ, Inst Pure & Appl Biol, Multan, Pakistan
[4] Bahauddin Zakariya Univ, Dept Stat, Multan, Pakistan
[5] Govt Coll Univ Faisalabad, Faisalabad, Pakistan
来源：
BRAZILIAN JOURNAL OF MICROBIOLOGY | 2019年 / 50卷 / 02期
关键词：
Tuberculosis; Polymorphism; EBI3 (rs4740); Smoking; PULMONARY TUBERCULOSIS; RECEPTOR; 2; INFECTION; PROTEIN; CELLS; RISK;
D O I：
10.1007/s42770-019-00048-8
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Tuberculosis is becoming a global issue with raising occurrences; particularly in developing countries, the situation is alarming. Besides environmental factors, host genetic factors are vital in disease development. A demographical and genotypic analysis in relation to tuberculosis commencement is conducted in a Pakistani population, and genotypic frequency of EBI3 (rs4740) was analyzed. Allelic frequencies of EBI3 (rs4740) were significantly associated with disease susceptibility in the reviewed population. Analysis for EBI3 (rs4740) genotyping showed a significant association of GG with reduced risk for disease. Moreover, females and older age found to be more perilous to develop TB while smoking and a family history of TB are additional risk factors for disease development. Further work with a larger population is necessary to identify the true causative variants of tuberculosis.
引用
收藏
页码：429 / 434
页数：6
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