Diagnostic and Clinical Impact of 18F-FDG PET/CT in Staging and Restaging Soft-Tissue Sarcomas of the Extremities and Trunk: Mono-Institutional Retrospective Study of a Sarcoma Referral Center

被引：19
作者：
Annovazzi, Alessio [1 ]
Rea, Sandra [1 ]
Zoccali, Carmine [2 ]
Sciuto, Rosa [1 ]
Baldi, Jacopo [2 ]
Anelli, Vincenzo [3 ]
Petrongari, Maria G. [4 ]
Pescarmona, Edoardo [5 ]
Biagini, Roberto [2 ]
Ferraresi, Virginia [6 ]
机构：
[1] IRCCS Regina Elena Natl Canc Inst, Nucl Med Unit, I-00144 Rome, Italy
[2] IRCCS Regina Elena Natl Canc Inst, Oncol Orthopaed Unit, I-00144 Rome, Italy
[3] IRCCS Regina Elena Natl Canc Inst, Radiol & Diagnost Imaging Unit, I-00144 Rome, Italy
[4] IRCCS Regina Elena Natl Canc Inst, Dept Radiat Oncol, I-00144 Rome, Italy
[5] IRCCS Regina Elena Natl Canc Inst, Clin Pathol, I-00144 Rome, Italy
[6] IRCCS Regina Elena Natl Canc Inst, Med Oncol 1, I-00144 Rome, Italy
来源：
JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 08期
关键词：
18F-FDG PET; CT; soft tissue sarcoma; patient management; staging; POSITRON-EMISSION-TOMOGRAPHY; FDG-PET/CT; NEOADJUVANT CHEMOTHERAPY; BONE; GRADE; METASTASIS;
D O I：
10.3390/jcm9082549
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Soft-tissue sarcomas (STS) represent a wide heterogeneous class of rare tumors. The exact role(18)F-fluorodeoxyglucose positron emission/computed tomography (F-18-FDG PET/CT) in the evaluation of STS is not well established. The aim of the present study was to evaluate how the use of(18)F-FDG PET/CT in STS could influence patient therapy planning, looking for a possible added value over computed tomography and magnetic resonance imaging-the most used modalities in the study of STS. Differences in SUV(max)according to histologic subtype and tumor grade were also considered. Methods: a total of 345 consecutive(18)F-FDG PET/CT scans performed for initial staging (n= 171) or for suspected disease relapse (n= 174) in 282 patients with STS extracted from the local Information System database were retrospectively reviewed. Results:F-18-FDG PET/CT altered therapy planning in 80 cases (16.4% for staging and 29.9% in restaging), both for disease upstaging (58.8%) and downstaging (41.2%) Conclusions:F-18-FDG PET/CT could significantly influence management of patients with STS, particularly for restaging.
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页码：1 / 12
页数：12
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