Diagnostic and Clinical Impact of 18F-FDG PET/CT in Staging and Restaging Soft-Tissue Sarcomas of the Extremities and Trunk: Mono-Institutional Retrospective Study of a Sarcoma Referral Center

被引：22

作者：

Annovazzi, Alessio ^{[1
]}

Rea, Sandra ^{[1
]}

Zoccali, Carmine ^{[2
]}

Sciuto, Rosa ^{[1
]}

Baldi, Jacopo ^{[2
]}

Anelli, Vincenzo ^{[3
]}

Petrongari, Maria G. ^{[4
]}

Pescarmona, Edoardo ^{[5
]}

Biagini, Roberto ^{[2
]}

Ferraresi, Virginia ^{[6
]}

机构：

[1] IRCCS Regina Elena Natl Canc Inst, Nucl Med Unit, I-00144 Rome, Italy

[2] IRCCS Regina Elena Natl Canc Inst, Oncol Orthopaed Unit, I-00144 Rome, Italy

[3] IRCCS Regina Elena Natl Canc Inst, Radiol & Diagnost Imaging Unit, I-00144 Rome, Italy

[4] IRCCS Regina Elena Natl Canc Inst, Dept Radiat Oncol, I-00144 Rome, Italy

[5] IRCCS Regina Elena Natl Canc Inst, Clin Pathol, I-00144 Rome, Italy

[6] IRCCS Regina Elena Natl Canc Inst, Med Oncol 1, I-00144 Rome, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 08期

关键词：

18F-FDG PET; CT; soft tissue sarcoma; patient management; staging; POSITRON-EMISSION-TOMOGRAPHY; FDG-PET/CT; NEOADJUVANT CHEMOTHERAPY; BONE; GRADE; METASTASIS;

D O I：

10.3390/jcm9082549

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Soft-tissue sarcomas (STS) represent a wide heterogeneous class of rare tumors. The exact role(18)F-fluorodeoxyglucose positron emission/computed tomography (F-18-FDG PET/CT) in the evaluation of STS is not well established. The aim of the present study was to evaluate how the use of(18)F-FDG PET/CT in STS could influence patient therapy planning, looking for a possible added value over computed tomography and magnetic resonance imaging-the most used modalities in the study of STS. Differences in SUV(max)according to histologic subtype and tumor grade were also considered. Methods: a total of 345 consecutive(18)F-FDG PET/CT scans performed for initial staging (n= 171) or for suspected disease relapse (n= 174) in 282 patients with STS extracted from the local Information System database were retrospectively reviewed. Results:F-18-FDG PET/CT altered therapy planning in 80 cases (16.4% for staging and 29.9% in restaging), both for disease upstaging (58.8%) and downstaging (41.2%) Conclusions:F-18-FDG PET/CT could significantly influence management of patients with STS, particularly for restaging.

引用

页码：1 / 12

页数：12

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