Comprehensive analysis of glycosaminoglycans from the edible shellfish

被引：16

作者：

Okamoto, Yusuke ^{[1
]}

Higashi, Kyohei ^{[1
]}

Linhardt, Robert J. ^{[2
]}

Toida, Toshihiko ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chuo Ku, 1-8-1 Inohana, Chiba 2608675, Japan

[2] Rensselaer Polytech Inst, Dept Biol, Ctr Biotechnol & Interdisciplinary Studies, Troy, NY 12180 USA

来源：

CARBOHYDRATE POLYMERS | 2018年 / 184卷

关键词：

Glycosaminoglycans; Edible shellfish; Disaccharide composition; New structures; 3-O-SULFATED GLUCURONIC-ACID; CHONDROITIN SULFATE K; ANTICOAGULANT ACTIVITY; DISACCHARIDE; HEPARIN; POLYSACCHARIDES; DEGRADATION;

D O I：

10.1016/j.carbpol.2017.12.076

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We have previously reported that the keratan sulfate (KS) disaccharide was branched to the C-3 position of glucuronate in chondroitin sulfate (CS)-E derived from the Mactra chinensis. We carried out the comprehensive disaccharide analysis of GAGs from 10 shellfish, Ruditapes philippinarum, Scapharca broughtonii, Mizuhopecten yessoensis, Turbo cornutus, Crassostrea nippona, Corbicula japonica, Mytilus galloprovincialis, Neptunea intersculpta, Pseudocardium sachalinense and Crassostrea gigas, to better understand the glycan structures in marine organisms. The contents of CS, heparan sulfate and hyaluronic acid and their compositions depend on the species of shellfish. Interestingly, a peak corresponding to a pentasaccharide containing KS disaccharide was observed when GAGs from T. cornutus was treated with chondroitinase (Chase) ACII but not Chase ABC. In addition, unidentified peaks were also observed when CS derived from R. philippinarum, S. broughtonii were treated with Chase ACII. These results suggest the presence of additional unidentified structure of CS in these shellfish.

引用

页码：269 / 276

页数：8

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