Organotins: A review of their reproductive toxicity, biochemistry, and environmental fate

被引:131
作者
Graceli, Jones Bernardes [1 ]
Sena, Gabriela Cavati [1 ]
Iguatemy Lopes, Pedro Francisco [1 ]
Zamprogno, Gabriela Carvalho [2 ]
da Costa, Mercia Barcellos [2 ]
Locateli Godoi, Ana Flavia [3 ]
dos Santos, Dayana Moscardi [4 ]
Rodrigues de Marchi, Mary Rosa [5 ]
dos Santos Fernandez, Marcos Antonio [6 ]
机构
[1] UFES Fed Univ Espirito Santo, Dept Morphol, Vitoria, ES, Brazil
[2] Univ Fed Espirito Santo, Dept Biol Sci, Vitoria, ES, Brazil
[3] UFPR Fed Univ Parana, Dept Environm Engn, Curitiba, Parana, Brazil
[4] Univ Sao Paulo, Inst Oceanog, Sao Paulo, Brazil
[5] UNESP Univ Estadual Paulista, Inst Chem, Araraquara, Brazil
[6] UERJ Rio de Janeiro State Univ, Dept Oceanog, Rio De Janeiro, Brazil
关键词
Organotins; Environmental fate; Biochemistry; Reproductive toxicity; Obesogens; SPRAGUE-DAWLEY RATS; RETINOID-X-RECEPTOR; FLAME PHOTOMETRIC DETECTION; TRIBUTYLTIN CHLORIDE; AROMATASE-ACTIVITY; IN-UTERO; DIBUTYLTIN DICHLORIDE; LIQUID-CHROMATOGRAPHY; LITTORINA-LITTOREA; GAS-CHROMATOGRAPHY;
D O I
10.1016/j.reprotox.2012.11.008
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The review purposes are to (1) evaluate the experimental evidence for adverse effects on reproduction and metabolism and (2) identify the current knowledge of analytical procedures, biochemistry and environmental aspects relating to organotins. Organotins are pollutants that are used as biocides in antifouling paints. They produce endocrine-disrupting effects in mollusks, such as imposex. In rodents, organotin exposure induces developmental and reproductive toxicity as well as alteration of metabolic homeostasis through its action as an obesogen. The adverse effects that appear in rodents have raised concerns about organotins' potential health risk to humans in relation to organotin exposure. At present, triorganotin, such as tributyltin, have been demonstrated to produce imposex, and mammalian reproductive and metabolic toxicity. For most mammals, triorganotin exposure predominantly occurs through the ingestion, and this compound can cross the placenta. With these risks in mind, it is important to improve our knowledge of organotins' effects on environmental health. (c) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:40 / 52
页数:13
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