Genomic Landscape of Pheochromocytoma and Paraganglioma

被引：90

作者：

Jochmanova, Ivana ^{[1
,2
]}

Pacak, Karel ^{[1
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA

[2] PJ Safarik Univ Kosice, Med Fac, Dept Internal Med 1, Trieda SNP 1, Kosice 04011, Slovakia

来源：

TRENDS IN CANCER | 2018年 / 4卷 / 01期

基金：

美国国家卫生研究院;

关键词：

MUTATIONS; CANCER;

D O I：

10.1016/j.trecan.2017.11.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent comprehensive molecular analysis allowed the identification of unique molecular signatures in pheochromocytomas (PHEOs) and paragangliomas (PGLs). Here we summarize the main pathway clusters activated by PHEO- and PGL-susceptibility genes: pseudohypoxic, kinase, and Wnt signaling. Molecular characterization and clustering of PHEOs and PGLs may help in the application of principles of personalized medicine and in decision making for targeted therapy of these tumors.

引用

页码：6 / 9

页数：5

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