Metal Complexes with Schiff Bases: Data Collection and Recent Studies on Biological Activities

被引：45
作者：
Sinicropi, Maria Stefania [1 ]
Ceramella, Jessica [1 ]
Iacopetta, Domenico [1 ]
Catalano, Alessia [2 ]
Mariconda, Annaluisa [3 ]
Rosano, Camillo [4 ]
Saturnino, Carmela [3 ]
El-Kashef, Hussein [5 ]
Longo, Pasquale [6 ]
机构：
[1] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy
[2] Univ Bari Aldo Moro, Dept Pharm Drug Sci, I-70126 Bari, Italy
[3] Univ Basilicata, Dept Sci, I-85100 Potenza, Italy
[4] IRCCS Policlin San Martino, Prote & Mass Spectrometry Unit, Largo Rosanna Benzi 10, I-16132 Genoa, Italy
[5] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt
[6] Univ Salerno, Dept Chem & Biol, Via Giovanni Paolo II 132, I-84084 Fisciano, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 23期
关键词：
Schiff bases; antibacterial; imine; antimicrobial; metal complexes; antiproliferative; antimalarial; antileishmanial; Alzheimer disease; diabetes; SPECTRAL CHARACTERIZATION; CRYSTAL-STRUCTURE; IN-SILICO; ANTIMALARIAL; DERIVATIVES; LIGANDS; CU(II); DNA;
D O I：
10.3390/ijms232314840
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metal complexes play a crucial role in pharmaceutical sciences owing to their wide and significant activities. Schiff bases (SBs) are multifaceted pharmacophores capable of forming chelating complexes with various metals in different oxidation states. Complexes with SBs are extensively studied for their numerous advantages, including low cost and simple synthetic strategies. They have been reported to possess a variety of biological activities, including antimicrobial, anticancer, antioxidant, antimalarial, analgesic, antiviral, antipyretic, and antidiabetic ones. This review summarizes the most recent studies on the antimicrobial and antiproliferative activities of SBs-metal complexes. Moreover, recent studies regarding mononuclear and binuclear complexes with SBs are described, including antioxidant, antidiabetic, antimalarial, antileishmanial, anti-Alzheimer, and catecholase activities.
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页数：20
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