The Role of HIF in Immunity and Inflammation

被引：511

作者：

McGettrick, Anne F. ^{[1
]}

O'Neill, Luke A. J. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci Inst, Dublin, Ireland

来源：

CELL METABOLISM | 2020年 / 32卷 / 04期

基金：

英国惠康基金;

关键词：

HYPOXIA-INDUCIBLE FACTOR; GERMINAL CENTER HYPOXIA; PYRUVATE-KINASE M2; DENDRITIC CELLS; T-CELLS; FACTOR-I; CUTTING EDGE; B-CELLS; BACTERIAL LIPOPOLYSACCHARIDE; TRANSCRIPTIONAL ACTIVITY;

D O I：

10.1016/j.cmet.2020.08.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt. HIF-alpha stabilization can also occur under normoxia during immunity and inflammation, where it regulatesmetabolismbut in addition can directly regulate expression of immune genes. Here we review the role of HIF in immunity, including its role inmacrophages, dendritic cells, neutrophils, T cells, and B cells. Its role in immunity is as essential for cellular responses as it is in its original role in hypoxia, with HIF being implicated in multiple inflammatory diseases and in immunosuppression in tumors.

引用

页码：524 / 536

页数：13

共 168 条

[1] Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination [J].

Abbott, Robert K. ;

Thayer, Molly ;

Labuda, Jasmine ;

Silva, Murillo ;

Philbrook, Phaethon ;

Cain, Derek W. ;

Kojima, Hidefumi ;

Hatfield, Stephen ;

Sethumadhavan, Shalini ;

Ohta, Akio ;

Reinherz, Ellis L. ;

Kelsoe, Garnett ;

Sitkovsky, Michail .

JOURNAL OF IMMUNOLOGY, 2016, 197 (10) :4014-4020

[2] HIF-1 α-regulated MIF activation and Nox2-dependent ROS generation promote Leishmania amazonensis killing by macrophages under hypoxia [J].

Alonso, Diego ;

Serrano, Edgar ;

Bermejo, Francisca J. ;

Corral, Ricardo S. .

CELLULAR IMMUNOLOGY, 2019, 335 :15-21

[3] Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes [J].

Altenberg, B ;

Greulich, KO .

GENOMICS, 2004, 84 (06) :1014-1020

[4]

[Anonymous], 2014, ISRN INFLAMM, DOI DOI 10.1155/2014/928461

[5]

[Anonymous], 2022, FRONT IMMUNOL, DOI [DOI 10.3389/FIMMU.2016.00518, DOI 10.3389/FIMMU.2022.829409]

[6] Dual role of hypoxia-inducible factor 1 α in experimental pulmonary tuberculosis: its implication as a new therapeutic target [J].

Baay-Guzman, Guillermina J. ;

Duran-Padilla, Marco A. ;

Rangel-Santiago, Jesus ;

Tirado-Rodriguez, Belen ;

Antonio-Andres, Gabriela ;

Barrios-Payan, Jorge ;

Mata-Espinosa, Dulce ;

Klunder-Klunder, Miguel ;

Vega, Mario I. ;

Hernandez-Pando, Rogelio ;

Huerta-Yepez, Sara .

FUTURE MICROBIOLOGY, 2018, 13 (07) :785-798

[7] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[8] HIV-1 Vpr Modulates Macrophage Metabolic Pathways: A SILAC-Based Quantitative Analysis [J].

Barrero, Carlos A. ;

Datta, Prasun K. ;

Sen, Satarupa ;

Deshmane, Satish ;

Amini, Shohreh ;

Khalili, Kamel ;

Merali, Salim .

PLOS ONE, 2013, 8 (07)

[9] A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells [J].

Barsoum, Ivraym B. ;

Smallwood, Chelsea A. ;

Siemens, D. Robert ;

Graham, Charles H. .

CANCER RESEARCH, 2014, 74 (03) :665-674

[10] Hypoxia Induces Escape from Innate Immunity in Cancer Cells via Increased Expression of ADAM10: Role of Nitric Oxide [J].

Barsoum, Ivraym B. ;

Hamilton, Thomas K. ;

Li, Xin ;

Cotechini, Tiziana ;

Miles, Ellen A. ;

Siemens, D. Robert ;

Graham, Charles H. .

CANCER RESEARCH, 2011, 71 (24) :7433-7441

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