Intrafollicular Levels of Matrix Metalloproteinases-2 and-9 in Patients with Polycystic Ovaries Are Not Associated with Pregnancy Rate During IVF Cycle

被引：0

作者：

Baka, Stavroula ^{[1
,2
]}

Zourla, Konstantina ^{[1
]}

Malamitsi-Puchner, Ariadne ^{[2
]}

Makrakis, Evangelos ^{[2
]}

Kaparos, George ^{[1
]}

Demeridou, Stella ^{[1
]}

Moustakarias, Theodore ^{[2
]}

Tzanakaki, Despoina ^{[2
]}

Hassiakos, Dimitris ^{[2
]}

Kouskouni, Evangelia ^{[1
]}

机构：

[1] Aretaie Univ Hosp, Dept Biopathol, Athens, Greece

[2] Aretaie Univ Hosp, Dept Obstet & Gynecol 2, IVF Unit, Athens, Greece

来源：

IN VIVO | 2009年 / 23卷 / 01期

关键词：

Matrix metalloproteinases; PCOS; follicular fluid; IVF; pregnancy; LUTEINIZED GRANULOSA-CELLS; IN-VITRO FERTILIZATION; NORMALLY OVULATING WOMEN; TISSUE INHIBITOR; FOLLICULAR-FLUID; MATRIX-METALLOPROTEINASE-9; EXPRESSION; SECRETION; MMP-9;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study aimed to detect the levels of matrix metalloproteinases (MMP)-2 and -9, using enzyme-linked immunosorbent assays, in the follicular fluid of 35 patients with polycystic ovaries, compare them with the levels found in 35 normally ovulating women enrolled in their first in vitro fertilization (IVF) cycle and then correlate them with pregnancy rates in these two groups. Levels of MMP-9 were found significantly increased in women with polycystic ovaries when compared with the controls, while MMP-2 levels were higher in women with polycystic ovaries without reaching statistical significance. The two groups did not differ in age, in the number of embryos transferred or in pregnancy rates. In conclusion, the results indicated an increased gelatinolytic activity in patients with polycystic ovaries after ovarian stimulation for IVF treatment without detecting any association between levels of MMP-2 and 9 and IVF pregnancy rates.

引用

页码：89 / 92

页数：4

共 21 条

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