Donghaesulfins A and B, Dimeric Benz[a]anthracene Thioethers from Volcanic Island Derived Streptomyces sp.

被引：20

作者：

Bae, Munhyung ^{[1
]}

An, Joon Soo ^{[1
]}

Bae, Eun Seo ^{[1
]}

Oh, Jedo ^{[1
]}

Park, So Hyun ^{[1
]}

Lim, Yeonjung ^{[2
]}

Ban, Yeon Hee ^{[3
]}

Kwon, Yun ^{[1
]}

Cho, Jang-Cheon ^{[2
]}

Yoon, Yeo Joon ^{[3
]}

Lee, Sang Kook ^{[1
]}

Shin, Jongheon ^{[1
]}

Oh, Dong-Chan ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Nat Prod Res Inst, Seoul 08826, South Korea

[2] Inha Univ, Dept Biol Sci, Incheon 22212, South Korea

[3] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

SULFUR; OHMYUNGSAMYCINS; ANTIBIOTICS;

D O I：

10.1021/acs.orglett.9b01057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chemical analysis of a Streptomyces strain, from a Korean volcanic island, discovered new benz[a]anthracene dimers linked by a thioether bond. The structures of donghaesulfins A and B (1 and 2) were elucidated by spectroscopic analysis including energy-dispersive X-ray. Their configurations were determined by ROESY NMR data, DP4 calculations, the modified Mosher's method, and ECD calculations. Donghaesulfins A (1) induced quinone reductase, whereas donghaesulfin B (2) displayed antiangiogenesis activity.

引用

页码：3635 / 3639

页数：5

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