Study of 1,3-dipolar cycloaddition of amino-acid azomethines and Juglone

被引：1

作者：

Syngaevsky, Vadym ^{[1
]}

Karkhut, Andrew ^{[1
]}

Polovkovych, Sviatoslav ^{[1
]}

Gzella, Andrzej ^{[2
]}

Lesyk, Roman ^{[3
,4
]}

Novikov, Volodymyr ^{[1
]}

机构：

[1] Lviv Polytech Natl Univ, Dept Technol Biol Act Subst Pharm & Biotechnol, Lvov, Ukraine

[2] Poznan Univ Med Sci, Dept Organ Chem, Poznan, Poland

[3] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmaceut Organ & Bioorgan Chem, Pekarska 69, UA-79010 Lvov, Ukraine

[4] Univ Informat Technol & Management Rzeszow, Fac Med, Dept Publ Hlth Dietet & Lifestyle Disorders, Rzeszow, Poland

来源：

SYNTHETIC COMMUNICATIONS | 2020年 / 50卷 / 20期

关键词：

13-cycloaddition; amino acids; azomethines; Juglone; X-ray; PROTEIN-KINASE-C; X=Y-ZH SYSTEMS; PYRROLIDINE DERIVATIVES; POTENTIAL 1,3-DIPOLES; TOPOISOMERASE-I; INHIBITOR; YLIDES; ATORVASTATIN; STRATEGY; PROLINE;

D O I：

10.1080/00397911.2020.1795880

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel 2,3,4,9-tetrahydro- and 4,9-dihydro-1H-benzo[f]isoindole derivatives were synthesized from Juglone and amino-acid azomethines in 74-85% yields via 1,3-dipolar cycloaddition. The stereo- and regioselectivity of cycloaddition was confirmed by NMR spectra and single-crystal X-ray diffraction analysis.

引用

页码：3165 / 3173

页数：9

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