Efficient One-Pot Synthesis of Spiro[indoline-3,1′-pyrazolo[1,2-b] phthalazine] Derivatives via Three-Component Reaction

被引：10
作者：
Chen, Hui [1 ]
Shi, Da-Qing [1 ]
机构：
[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2013年 / 50卷 / 01期
关键词：
SILICA SULFURIC-ACID; VIRUS 3C PROTEINASE; 1,3-DIPOLAR CYCLOADDITION; MULTICOMPONENT REACTIONS; SPIROOXINDOLE DERIVATIVES; 1,5-DIARYLPYRAZOLE CLASS; REGIOSELECTIVE SYNTHESIS; AQUEOUS-MEDIUM; SOLID-PHASE; AGENTS;
D O I：
10.1002/jhet.993
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient one-pot synthesis of spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] derivatives via three-component reaction of phthalhydrazide, isatin, and malononitrile (cyanoacetic ester) is described. This new protocol has the advantages of high efficiency, mild reaction conditions, one-pot procedure, and convenient operation.
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页码：56 / 60
页数：5
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