Elimination mechanisms of therapeutic monoclonal antibodies

被引：379
作者：
Tabrizi, MA
Tseng, CML
Roskos, LK
机构：
[1] Abgenix, Fremont, CA 94556 USA
[2] Sanofi Aventis, Global Metab & Pharmacokinet, Bridgewater, NJ 08807 USA
来源：
DRUG DISCOVERY TODAY | 2006年 / 11卷 / 1-2期
关键词：
D O I：
10.1016/S1359-6446(05)03638-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Targeted therapies using monoclonal antibodies have achieved important therapeutic applications in the treatment of various human diseases. Understanding the factors that impact the pharmacokinetics of monoclonal antibodies is of high importance for effective therapy. Many factors related to the target antigen, antibody and patients can affect antibody elimination. Evaluation of these factors will facilitate the understanding of the processes involved in antibody elimination.
引用
收藏
页码：81 / 88
页数：8
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