Rasagiline for dysexecutive symptoms during wearing-off in Parkinson's disease: a pilot study

被引：9
作者：
Rinaldi, Domiziana [1 ]
Assogna, Francesca [2 ,3 ,4 ]
Sforza, Michela [1 ]
Tagliente, Stefania [1 ]
Pontieri, Francesco E. [1 ,4 ]
机构：
[1] Sapienza Univ Roma, Dipartimento Neurosci Salute Mentale & Organi Sen, Via Grottarossa 1035, I-00189 Rome, Italy
[2] Museo Storico Fis, Piazza Viminale 1, Rome, Italy
[3] Centro Studi & Ric Enrico Fermi, Piazza Viminale 1, Rome, Italy
[4] IRCCS, Fdn Santa Lucia, Via Ardeatina 306, I-00179 Rome, Italy
来源：
NEUROLOGICAL SCIENCES | 2018年 / 39卷 / 01期
关键词：
Cognition; Frontal Assessment Battery; Parkinson's disease; Rasagiline; Wearing-off;
D O I：
10.1007/s10072-017-3123-2
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Wearing-off refers to the predictable worsening of motor and sometimes non-motor symptoms of Parkinson's disease occurring at the end of levodopa dose that improves with the next drug dose. Here, we investigated the efficacy of rasagiline on executive functions at the end of levodopa dose in patients displaying symptoms of wearing-off. Rasagiline was well-tolerated and produced a significant improvement at the Frontal Assessment Battery, together with improvement of motor symptoms at the end of levodopa dose. These results suggest that treatment of motor symptoms of wearing-off with rasagiline may be accompanied by improvement of executive functions, and further support the need for optimizing dopamine replacement therapy in fluctuating Parkinson's disease patients.
引用
收藏
页码：141 / 143
页数：3
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