Nutritional n-3 polyunsaturated fatty acids deficiency alters cannabinoid receptor signaling pathway in the brain and associated anxiety-like behavior in mice

被引:86
作者
Larrieu, Thomas [1 ,2 ]
Madore, Charlotte [1 ,2 ]
Joffre, Corinne [1 ,2 ]
Laye, Sophie [1 ,2 ]
机构
[1] Univ Victor Segalen, INRA, UMR 1286, F-33076 Bordeaux, France
[2] Univ Bordeaux, F-33077 Bordeaux, France
关键词
CB1; DHA; Anxiety; MAPK; Endocannabinoid; DOCOSAHEXAENOIC ACID; DEPRESSION; CB1; STIMULATION; DEPRIVATION; RATS; EXPRESSION; REGIONS; STRESS; SYSTEM;
D O I
10.1007/s13105-012-0179-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
N-3 polyunsaturated fatty acids (PUFAs) cannot be synthesized de novo in mammals and need to be provided by dietary means. In the brain, the main n-3 PUFA is docosahexaenoic acid (DHA), which is a key component of neuronal membranes. A low dietary level of DHA has been associated with increased risk of developing neuropsychiatric diseases; however, the mechanisms involved remain to be determined. In this study, we found that long-term exposure to an n-3 deficient diet decreases the level of DHA in the brain and impairs the cannabinoid receptor signaling pathway in mood-controlling structures. In n-3 deficient mice, the effect of the cannabinoid agonist WIN55,212-2 in an anxiety-like behavior test was abolished. In addition, the cannabinoid receptor signaling pathways were altered in the prefrontal cortex and the hypothalamus. Consequently, our data suggest that behavioral changes linked to an n-3 dietary deficiency are due to an alteration in the endocannabinoid system in specific brain areas.
引用
收藏
页码:671 / 681
页数:11
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