Synthesis of 7α-hydroxy-dehydroepiandrosterone and 7β-hydroxy-dehydroepiandrosterone

被引：48

作者：

Li, HP ^{[1
]}

Liu, HM ^{[1
]}

Ge, WZ ^{[1
]}

Huang, LH ^{[1
]}

Shan, LH ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Chem, Zhengzhou 450052, Peoples R China

来源：

STEROIDS | 2005年 / 70卷 / 14期

关键词：

microbial transformation; DHEA; hydroxylation; Mucor racemosus; 7-hydroxy;

D O I：

10.1016/j.steroids.2005.07.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fermentation of dehydroepiandrosterone synthesized from the starting material diosgenin using Mucor racemosus produced 7 alpha-hydroxy-dehydroepiandrosterone and 7 beta-hydroxy-dehydroepiandrosterone. The bioactivity of the microbial metabolites is also discussed. The species M. racemosus was isolated by screening among stains from soil samples collected from various parts of China. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：970 / 973

页数：4

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