Advanced therapy medicinal products and health technology assessment principles and practices for value-based and sustainable healthcare

BackgroundAdvanced therapy medicinal products (ATMPs) are beginning to reach European markets, and questions are being asked about their value for patients and how healthcare systems should pay for them.ObjectivesTo identify and discuss potential challenges of ATMPs in view of current health technology assessment (HTA) methodologyspecifically economic evaluation methodsin Europe as it relates to ATMPs, and to suggest potential solutions to these challenges.MethodsAn Expert Panel reviewed current HTA principles and practices in relation to the specific characteristics of ATMPs.ResultsThree key topics were identified and prioritised for discussionuncertainty, discounting, and health outcomes and value. The panel discussed that evidence challenges linked to increased uncertainty may be mitigated by collection of follow-on data, use of value of information analysis, and/or outcomes-based contracts. For discount rates, an international, multi-disciplinary forum should be established to consider the economic, social and ethical implications of the choice of rate. Finally, consideration of the feasibility of assessing the value of ATMPs beyond health gain may also be key for decision-making.ConclusionsATMPs face a challenge in demonstrating their value within current HTA frameworks. Consideration of current HTA principles and practices with regards to the specific characteristics of ATMPs and continued dialogue will be key to ensuring appropriate market access.Classification codeI.