Long noncoding RNA LINP1 acts as an oncogene and promotes chemoresistance in breast cancer

被引：71

作者：

Liang, Yiran ^{[1
]}

Li, Yaming ^{[1
]}

Song, Xiaojin ^{[1
]}

Zhang, Ning ^{[1
]}

Sang, Yuting ^{[1
]}

Zhang, Hanwen ^{[1
]}

Liu, Ying ^{[1
]}

Chen, Bing ^{[2
]}

Zhao, Wenjing ^{[2
]}

Wang, Lijuan ^{[2
]}

Guo, Renbo ^{[3
]}

Yu, Zhigang ^{[4
]}

Yang, Qifeng ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Breast Surg, Wenhua Xi Rd 107, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Qilu Hosp, Pathol Tissue Bank, Jinan, Shandong, Peoples R China

[3] Shandong Univ, Dept Urol, Shandong Canc Hosp, Jinan, Shandong, Peoples R China

[4] Shandong Univ, Hosp 2, Dept Breast Surg, Jinan, Shandong, Peoples R China

来源：

CANCER BIOLOGY & THERAPY | 2018年 / 19卷 / 02期

基金：

中国国家自然科学基金;

关键词：

LINP1; oncogene; chemoresistance; breast cancer; POOR-PROGNOSIS; DRUG-RESISTANCE; DOWN-REGULATION; CELL-CYCLE; METASTASIS; PROLIFERATION; EXPRESSION; MEG3; PROGRESSION; EVOLUTION;

D O I：

10.1080/15384047.2017.1394543

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies have shown that long non-coding RNAs (lncRNAs) are involved in a number of biological processes; however, further study is still warranted to comprehensively reveal their functions. In this study, we showed that the lncRNA in non-homologous end joining (NHEJ) pathway 1 (LINP1) was related to breast cancer cell proliferation, metastasis and chemoresistance. Loss- and gain-of function studies were used to assess the role of LINP1 in promoting breast cancer progression. LINP1 knockdown mitigated breast cancer cell growth by inducing G1-phase cell cycle arrest and apoptosis. LINP1 also promoted breast cancer cell metastasis and influenced the expression of epithelial-mesenchymal transition-related markers. We identified p53 as a regulator of LINP1, and LINP1 overexpression could restore the metastatic effects of p53. Furthermore, LINP1 was upregulated in doxorubicin- and 5-fluorouracil-resistant cells and induced chemoresistance. We also observed that LINP1 enrichment played a critical functional role in chemoresistance by inhibiting chemotherapeutics-induced apoptosis. Moreover, LINP1 in tumors was associated with lower overall survival and disease-free survival. In conclusion, LINP1 may serve as a potential oncogene and chemoresistance-related regulator of breast cancer cells, suggesting that LINP1 might be a potent therapeutic target and might reduce chemoresistance in breast cancer.

引用

页码：120 / 131

页数：12

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