A Multicenter Retrospective Case Study of Anaphylaxis Triggers by Age in Korean Children

被引：79

作者：

Lee, So-Yeon ^{[1
]}

Ahn, Kangmo ^{[2
]}

Kim, Jihyun ^{[2
]}

Jang, Gwang Cheon ^{[3
]}

Min, Taek Ki ^{[4
]}

Yang, Hyeon-Jong ^{[4
]}

Pyun, Bok Yang ^{[4
]}

Kwon, Ji-Won ^{[5
]}

Sohn, Myung Hyun ^{[6
]}

Kim, Kyung Won ^{[6
]}

Kim, Kyu-Earn ^{[6
]}

Yu, Jinho ^{[7
]}

Hong, Soo-Jong ^{[7
]}

Kwon, Jung Hyun ^{[8
]}

Kim, Sung-Won ^{[9
]}

Song, Tae Won ^{[10
]}

Kim, Woo Kyung ^{[10
]}

Kim, Hyung Young ^{[11
]}

Jeon, You Hoon ^{[1
]}

Lee, Yong Ju ^{[1
]}

Lee, Hae Ran ^{[1
]}

Kim, Hye-Young ^{[11
]}

Ahn, Youngmin ^{[12
]}

Yum, Hye Yung ^{[13
]}

Suh, Dong In ^{[5
]}

Kim, Hyun Hee ^{[14
]}

Kim, Jin-Tack ^{[14
]}

Kim, Jeong Hee ^{[15
]}

Park, Yong Mean ^{[16
]}

Lee, Sooyoung ^{[17
]}

机构：

[1] Hallym Univ, Coll Med, Dept Pediat, Seoul, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, Seoul, South Korea

[3] Ilsan Hosp, Natl Hlth Insurance Corp, Dept Pediat, Seoul, South Korea

[4] Soonchunhyang Univ Hosp, Dept Pediat, Seoul, South Korea

[5] Seoul Natl Univ, Coll Med, Dept Pediat, Seoul, South Korea

[6] Yonsei Univ, Coll Med, Dept Pediat, Seoul, South Korea

[7] Univ Ulsan, Coll Med, Dept Pediat, Seoul, South Korea

[8] Korea Univ, Coll Med, Dept Pediat, Seoul, South Korea

[9] Pusan St Maria Hosp, Dept Pediat, Busan, South Korea

[10] Inje Univ, Coll Med, Dept Pediat, Seoul, South Korea

[11] Pusan Natl Univ, Sch Med, Dept Pediat, Yangsan, South Korea

[12] Eulji Univ, Sch Med, Dept Pediat, Seoul, South Korea

[13] Seoul Med Ctr, Dept Pediat, Seoul, South Korea

[14] Catholic Univ Korea, Coll Med, Dept Pediat, Seoul, South Korea

[15] Inha Univ, Coll Med, Dept Pediat, Inchon, South Korea

[16] Konkuk Univ, Sch Med, Dept Pediat, Seoul, South Korea

[17] Ajou Univ, Sch Med, Dept Pediat, Suwon, South Korea

来源：

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | 2016年 / 8卷 / 06期

关键词：

Anaphylaxis; children; epidemiology; ALLERGIC REACTIONS; NATURAL-HISTORY; MILK ALLERGY; NUT ALLERGY; PREDICTORS; FEATURES; OUTCOMES; PEANUT; COHORT; ASTHMA;

D O I：

10.4168/aair.2016.8.6.535

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Purpose: Although anaphylaxis is recognized as an important, life-threatening condition, data are limited regarding its triggers in different age groups. We aimed to identify anaphylaxis triggers by age in Korean children. Methods: We performed a retrospective review of medical records for children diagnosed with anaphylaxis between 2009 and 2013 in 23 secondary or tertiary hospitals in South Korea. Results: A total of 991 cases (mean age = 5.89 +/- 5.24) were reported, with 63.9% involving patients younger than 6 years of age and 66% involving male children. Food was the most common anaphylaxis trigger (74.7%), followed by drugs and radiocontrast media (10.7%), idiopathic factors (9.2%), and exercise (3.6%). The most common food allergen was milk (28.4%), followed by egg white (13.6%), walnut (8.0%), wheat (7.2%), buckwheat (6.5%), and peanut (6.2%). Milk and seafood were the most common anaphylaxis triggers in young and older children, respectively. Drug-triggered anaphylaxis was observed more frequently with increasing age, with antibiotics (34.9%) and nonsteroidal anti-inflammatory drugs (17.9%) being the most common causes. Conclusions: The most common anaphylaxis trigger in Korean children was food. Data on these triggers show that their relative frequency may vary by age.

引用

页码：535 / 540

页数：6

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