Breaking bad: R-loops and genome integrity

被引：255

作者：

Sollier, Julie ^{[1
]}

Cimprich, Karlene A. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem & Syst Biol, Sch Med, Stanford, CA 94305 USA

来源：

TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 09期

基金：

美国国家卫生研究院;

关键词：

R-loop; gene expression; genomic instability; epigenomic stability; RNA/DNA HYBRIDS; SWITCH REGIONS; TRANSCRIPTION; REPLICATION; INSTABILITY; GENE; MECHANISMS; SENATAXIN; CHROMATIN; CLEAVAGE;

D O I：

10.1016/j.tcb.2015.05.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

R-loops, nucleic acid structures consisting of an RNA DNA hybrid and displaced single-stranded (ss) DNA, are ubiquitous in organisms from bacteria to mammals. First described in bacteria where they initiate DNA replication, it now appears that R-loops regulate diverse cellular processes such as gene expression, immunoglobulin (Ig) class switching, and DNA repair. Changes in R-loop regulation induce DNA damage and genome instability, and recently it was shown that R-loops are associated with neurodegenerative disorders. We discuss recent developments in the field; in particular, the regulation and effects of R-loops in cells, their effect on genomic and epigenomic stability, and their potential contribution to the origin of diseases including cancer and neurodegenerative disorders.

引用

页码：514 / 522

页数：9

共 42 条

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