Breaking bad: R-loops and genome integrity

被引：255
作者：
Sollier, Julie [1 ]
Cimprich, Karlene A. [1 ]
机构：
[1] Stanford Univ, Dept Chem & Syst Biol, Sch Med, Stanford, CA 94305 USA
来源：
TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 09期
基金：
美国国家卫生研究院;
关键词：
R-loop; gene expression; genomic instability; epigenomic stability; RNA/DNA HYBRIDS; SWITCH REGIONS; TRANSCRIPTION; REPLICATION; INSTABILITY; GENE; MECHANISMS; SENATAXIN; CHROMATIN; CLEAVAGE;
D O I：
10.1016/j.tcb.2015.05.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
R-loops, nucleic acid structures consisting of an RNA DNA hybrid and displaced single-stranded (ss) DNA, are ubiquitous in organisms from bacteria to mammals. First described in bacteria where they initiate DNA replication, it now appears that R-loops regulate diverse cellular processes such as gene expression, immunoglobulin (Ig) class switching, and DNA repair. Changes in R-loop regulation induce DNA damage and genome instability, and recently it was shown that R-loops are associated with neurodegenerative disorders. We discuss recent developments in the field; in particular, the regulation and effects of R-loops in cells, their effect on genomic and epigenomic stability, and their potential contribution to the origin of diseases including cancer and neurodegenerative disorders.
引用
收藏
页码：514 / 522
页数：9
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